Background: Galectin-3 (Gal-3) is an anti-apoptotic molecule involved in thyroid cells transformation. It is specifically overexpressed in thyroid tumour cells and is currently used as a preoperative diagnostic marker of thyroid malignancy. Gal-3 expression is downregulated by wt-p53 at the transcriptional level. In well-differentiated thyroid carcinomas (WDTCs) there is an unexplained paradoxical concomitant expression of Gal-3 and wt-p53. HIPK2 is a co-regulator of different transcription factors, and modulates basic cellular processes mainly through the activation of wt-p53. Since we demonstrated that HIPK2 is involved in p53-mediated Gal-3 downregulation, we asked whether HIPK2 deficiency might be responsible for such paradoxical Gal-3 overexpression in WDTC.
The loss of the p53 activator HIPK2 is responsible for Galectin-3 overexpression in well differentiated thyroid carcinomas / Sciacchitano, Salvatore; Lavra, Luca; Luciani, Emidio; P., Fidanza; Giacomelli, Laura; Bellotti, Carlo; C., Rinaldo; M., Trovato; S., Soddu; A., Bartolazzi. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 1720-8386. - STAMPA. - 33 Suppl. to N 4:(2010), pp. 5-5. (Intervento presentato al convegno XXXIV Congresso Nazionale della Società di Endocrinologia tenutosi a Pisa nel 10-12-Giugno 2010).
The loss of the p53 activator HIPK2 is responsible for Galectin-3 overexpression in well differentiated thyroid carcinomas
SCIACCHITANO, Salvatore;LAVRA, Luca;LUCIANI, Emidio;GIACOMELLI, Laura;BELLOTTI, Carlo;
2010
Abstract
Background: Galectin-3 (Gal-3) is an anti-apoptotic molecule involved in thyroid cells transformation. It is specifically overexpressed in thyroid tumour cells and is currently used as a preoperative diagnostic marker of thyroid malignancy. Gal-3 expression is downregulated by wt-p53 at the transcriptional level. In well-differentiated thyroid carcinomas (WDTCs) there is an unexplained paradoxical concomitant expression of Gal-3 and wt-p53. HIPK2 is a co-regulator of different transcription factors, and modulates basic cellular processes mainly through the activation of wt-p53. Since we demonstrated that HIPK2 is involved in p53-mediated Gal-3 downregulation, we asked whether HIPK2 deficiency might be responsible for such paradoxical Gal-3 overexpression in WDTC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
