SUPPRESSION OF SRC-INDUCED TRANSFORMED PHENOTYPE BY EXPRESSION OF TROPOMYOSIN-1

Prasad, Gl; Masuelli, Laura; Raj, Mhg; Harindranath, N.

doi:10.1038/sj.onc.1202264

Suppression of high M(r) tropomyosins (TMs) is a common feature of transformed cells. Previous work from this laboratory has demonstrated that the isoform 1 of TM, TM1, acts as an anti-oncogene in ras-transformed murine fibroblasts. In this study, we have investigated whether TM1 is a ras-specific suppressor, or a general suppressor protein of the cellular transformation. V-src transformed fibroblasts, which express decreased TM1, were transduced with a full-length cDNA to overexpress TM1. Both the control and the transduced cells expressed v-src kinase at comparable levels. TM1 expressing (src-T1) cells grew at a lower rate in monolayer, exhibited well spread, flat morphology than the control cells. Enhanced expression of TM1 resulted in improved microfilamental architecture. More significantly, src-T1 cells completely failed to grow under anchorage independent conditions. These data demonstrate that TM1 is as an anti-oncogene of functionally diverse oncogenes, and it is a class II tumor suppressor protein.

SUPPRESSION OF SRC-INDUCED TRANSFORMED PHENOTYPE BY EXPRESSION OF TROPOMYOSIN-1 / Prasad, Gl; Masuelli, Laura; Raj, Mhg; Harindranath, N.. - In: ONCOGENE. - ISSN 0950-9232. - 18(1999), pp. 2027-2032. [10.1038/sj.onc.1202264]

Scheda prodotto non validato

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Titolo:	SUPPRESSION OF SRC-INDUCED TRANSFORMED PHENOTYPE BY EXPRESSION OF TROPOMYOSIN-1
Autori:	PRASAD GL MASUELLI, Laura RAJ MHG HARINDRANATH N. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1999
Rivista:	ONCOGENE
Citazione:	SUPPRESSION OF SRC-INDUCED TRANSFORMED PHENOTYPE BY EXPRESSION OF TROPOMYOSIN-1 / Prasad, Gl; Masuelli, Laura; Raj, Mhg; Harindranath, N.. - In: ONCOGENE. - ISSN 0950-9232. - 18(1999), pp. 2027-2032. [10.1038/sj.onc.1202264]
Handle:	http://hdl.handle.net/11573/41735
Appartiene alla tipologia:	01a Articolo in rivista

File allegati a questo prodotto

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11573/41735

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Catalogo dei prodotti della ricerca

Scheda prodotto non validato

File allegati a questo prodotto