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EnglishSuppression of high M(r) tropomyosins (TMs) is a common feature of transformed cells. Previous work from this laboratory has demonstrated that the isoform 1 of TM, TM1, acts as an anti-oncogene in ras-transformed murine fibroblasts. In this study, we have investigated whether TM1 is a ras-specific suppressor, or a general suppressor protein of the cellular transformation. V-src transformed fibroblasts, which express decreased TM1, were transduced with a full-length cDNA to overexpress TM1. Both the control and the transduced cells expressed v-src kinase at comparable levels. TM1 expressing (src-T1) cells grew at a lower rate in monolayer, exhibited well spread, flat morphology than the control cells. Enhanced expression of TM1 resulted in improved microfilamental architecture. More significantly, src-T1 cells completely failed to grow under anchorage independent conditions. These data demonstrate that TM1 is as an anti-oncogene of functionally diverse oncogenes, and it is a class II tumor suppressor protein.
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| Titolo: | SUPPRESSION OF SRC-INDUCED TRANSFORMED PHENOTYPE BY EXPRESSION OF TROPOMYOSIN-1 |
| Autori: | |
| Data di pubblicazione: | 1999 |
| Rivista: | |
| Handle: | http://hdl.handle.net/11573/41735 |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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