The hormonal responsiveness of plasma membrane-bound enzymes (Na+-K+)-ATPase and adenylate cyclase has been investigated in normal and regenerting rat liver. (Na+-K+)-ATPase basal activity is not affected by surgery and only slightly affected by partial hepatectomy; its response to epinephrine and cyclic AMP is decreased only 15 h after hepatectomy. Adenylate cyclase activity of plasma membranes from untreated animals is stimulated by parathyroid hormone and thyroxine; partial hepatectomy increased basal activity as well as the stimulation exerted by the aforementioned hormones, when glucagon and epinephrine sensitivity is essentially unaltered. © 1975.
Hormone responsiveness of plasma membrane-bound enzymes in normal and regenerating rat liver / S., Leoni; P., Luly; M. T., Mangiantini; S., Spagnuolo; A., Trentalance; Verna, Roberto. - In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. - ISSN 0005-2736. - STAMPA. - 394:2(1975), pp. 317-322.
Hormone responsiveness of plasma membrane-bound enzymes in normal and regenerating rat liver
VERNA, Roberto
1975
Abstract
The hormonal responsiveness of plasma membrane-bound enzymes (Na+-K+)-ATPase and adenylate cyclase has been investigated in normal and regenerting rat liver. (Na+-K+)-ATPase basal activity is not affected by surgery and only slightly affected by partial hepatectomy; its response to epinephrine and cyclic AMP is decreased only 15 h after hepatectomy. Adenylate cyclase activity of plasma membranes from untreated animals is stimulated by parathyroid hormone and thyroxine; partial hepatectomy increased basal activity as well as the stimulation exerted by the aforementioned hormones, when glucagon and epinephrine sensitivity is essentially unaltered. © 1975.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.