The activity of total, Mg++ dependent and Na+/K+ ATPase as well as the content of cAMP and cGMP in homogenates of human brain tumors have been investigated. Results are compared to values obtained from normal cortices. Na+/K+ ATPase and cAMP are decreased with a close relationship with the degree of malignancy, while Mg++ dependent activity is lower than in normal cortex but with no differences between the various tumors, and cGMP is unaffected. We conclude with a discussion on the metabolism of brain tumors and the suggestion of Na+/K+ ATPase activity as a marker of the malignancy of neoplastic growth.
Na+/K+ ATPase and cell growth IV: A metabolic marker of human brain tumors? / Verna, Roberto; Nardi, P.; Muraro, R.; Delfini, R.; Frati, L.. - In: JOURNAL OF NEUROSURGICAL SCIENCES. - ISSN 0390-5616. - STAMPA. - 27:2(1983), pp. 77-82.
Na+/K+ ATPase and cell growth IV: A metabolic marker of human brain tumors?
VERNA, Roberto;R. Delfini;
1983
Abstract
The activity of total, Mg++ dependent and Na+/K+ ATPase as well as the content of cAMP and cGMP in homogenates of human brain tumors have been investigated. Results are compared to values obtained from normal cortices. Na+/K+ ATPase and cAMP are decreased with a close relationship with the degree of malignancy, while Mg++ dependent activity is lower than in normal cortex but with no differences between the various tumors, and cGMP is unaffected. We conclude with a discussion on the metabolism of brain tumors and the suggestion of Na+/K+ ATPase activity as a marker of the malignancy of neoplastic growth.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
