We evaluated the effect of a one-year treatment of low dose methotrexate (MTX) on class specific rheumatoid factors in 27 patients with rheumatoid arthritis (RA). Enzyme-linked immunosorbent assay (ELISA) showed after 6 and 12 months a significant reduction of IgM-RF, IgA-RF and IgG-RF levels from the baseline values. During MTX treatment, changes of each RF isotype were not correlated with any other isotype and its corresponding immunoglobulin changes. Moreover, immunological changes were not related to the improvement of clinical parameters. Our results showed that low dose MTX can specifically affect levels of RF isotypes, which are involved in the immune pathogenesis of RA.

ONE-YEAR TREATMENT WITH LOW-DOSE METHOTREXATE IN RHEUMATOID-ARTHRITIS - EFFECT ON CLASS-SPECIFIC RHEUMATOID FACTORS / Spadaro, Antonio; Riccieri, Valeria; SILI SCAVALLI, Antonio; Taccari, Egisto; Zoppini, Antonio. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 12:3(1993), pp. 357-360. [10.1007/bf02231579]

ONE-YEAR TREATMENT WITH LOW-DOSE METHOTREXATE IN RHEUMATOID-ARTHRITIS - EFFECT ON CLASS-SPECIFIC RHEUMATOID FACTORS

SPADARO, Antonio;RICCIERI, Valeria;SILI SCAVALLI, Antonio;TACCARI, Egisto;ZOPPINI, Antonio
1993

Abstract

We evaluated the effect of a one-year treatment of low dose methotrexate (MTX) on class specific rheumatoid factors in 27 patients with rheumatoid arthritis (RA). Enzyme-linked immunosorbent assay (ELISA) showed after 6 and 12 months a significant reduction of IgM-RF, IgA-RF and IgG-RF levels from the baseline values. During MTX treatment, changes of each RF isotype were not correlated with any other isotype and its corresponding immunoglobulin changes. Moreover, immunological changes were not related to the improvement of clinical parameters. Our results showed that low dose MTX can specifically affect levels of RF isotypes, which are involved in the immune pathogenesis of RA.
1993
elisa; methotrexate; rheumatoid arthritis; rheumatoid factors
01 Pubblicazione su rivista::01a Articolo in rivista
ONE-YEAR TREATMENT WITH LOW-DOSE METHOTREXATE IN RHEUMATOID-ARTHRITIS - EFFECT ON CLASS-SPECIFIC RHEUMATOID FACTORS / Spadaro, Antonio; Riccieri, Valeria; SILI SCAVALLI, Antonio; Taccari, Egisto; Zoppini, Antonio. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 12:3(1993), pp. 357-360. [10.1007/bf02231579]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/417060
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