We evaluated the effect of a one-year treatment of low dose methotrexate (MTX) on class specific rheumatoid factors in 27 patients with rheumatoid arthritis (RA). Enzyme-linked immunosorbent assay (ELISA) showed after 6 and 12 months a significant reduction of IgM-RF, IgA-RF and IgG-RF levels from the baseline values. During MTX treatment, changes of each RF isotype were not correlated with any other isotype and its corresponding immunoglobulin changes. Moreover, immunological changes were not related to the improvement of clinical parameters. Our results showed that low dose MTX can specifically affect levels of RF isotypes, which are involved in the immune pathogenesis of RA.
ONE-YEAR TREATMENT WITH LOW-DOSE METHOTREXATE IN RHEUMATOID-ARTHRITIS - EFFECT ON CLASS-SPECIFIC RHEUMATOID FACTORS / Spadaro, Antonio; Riccieri, Valeria; SILI SCAVALLI, Antonio; Taccari, Egisto; Zoppini, Antonio. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 12:3(1993), pp. 357-360. [10.1007/bf02231579]
ONE-YEAR TREATMENT WITH LOW-DOSE METHOTREXATE IN RHEUMATOID-ARTHRITIS - EFFECT ON CLASS-SPECIFIC RHEUMATOID FACTORS
SPADARO, Antonio;RICCIERI, Valeria;SILI SCAVALLI, Antonio;TACCARI, Egisto;ZOPPINI, Antonio
1993
Abstract
We evaluated the effect of a one-year treatment of low dose methotrexate (MTX) on class specific rheumatoid factors in 27 patients with rheumatoid arthritis (RA). Enzyme-linked immunosorbent assay (ELISA) showed after 6 and 12 months a significant reduction of IgM-RF, IgA-RF and IgG-RF levels from the baseline values. During MTX treatment, changes of each RF isotype were not correlated with any other isotype and its corresponding immunoglobulin changes. Moreover, immunological changes were not related to the improvement of clinical parameters. Our results showed that low dose MTX can specifically affect levels of RF isotypes, which are involved in the immune pathogenesis of RA.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.