An immunohistochemical study on a case of lupus erythematosus panniculitis (LEP), without discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE) signs, showed that the cells in skin infiltrates were immunologically committed lymphocytes (OKT4, OKT8, OKT11 and HLA-DR positive cells) and elements of the monocyte-macrophage lineage (Leu M3 and Leu M5 positive). No immunophenotypically identifiable B-lymphocytes were seen. Immunofluorescent IgG, IgM, C3 and C4 deposits were found in blood vessel walls of the deep dermis. These findings, similar to that described in the skin changes of SLE and DLE, suggest that immunological mechanisms are operative in localized LEP, where the dermal lesions are the only expression of the disease.
LUPUS-ERYTHEMATOSUS PANNICULITIS - AN IMMUNOHISTOCHEMICAL STUDY / Riccieri, Valeria; SILI SCAVALLI, Antonio; Spadaro, Antonio; Taccari, Egisto; Zoppini, Antonio. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 13:4(1994), pp. 641-644. [10.1007/bf02243010]
LUPUS-ERYTHEMATOSUS PANNICULITIS - AN IMMUNOHISTOCHEMICAL STUDY
RICCIERI, Valeria;SILI SCAVALLI, Antonio;SPADARO, Antonio;TACCARI, Egisto;ZOPPINI, Antonio
1994
Abstract
An immunohistochemical study on a case of lupus erythematosus panniculitis (LEP), without discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE) signs, showed that the cells in skin infiltrates were immunologically committed lymphocytes (OKT4, OKT8, OKT11 and HLA-DR positive cells) and elements of the monocyte-macrophage lineage (Leu M3 and Leu M5 positive). No immunophenotypically identifiable B-lymphocytes were seen. Immunofluorescent IgG, IgM, C3 and C4 deposits were found in blood vessel walls of the deep dermis. These findings, similar to that described in the skin changes of SLE and DLE, suggest that immunological mechanisms are operative in localized LEP, where the dermal lesions are the only expression of the disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.