Idiopathic retroperitoneal fibrosis (RBF) is characterized by the development of a fibrotic mass surrounding the abdominal aorta and its branches, of unknown aetiology, Several immunlogical mechanisms can be operative in the pathogenesis of RPF. Based on this assumption we treated a patient affected by idiopathic RPF with low-dose methotrexate (MTX) therapy, To our knowledge this is the first example of the effectiveness and safety of a long-term low-dose MTX treatment in the post-surgical management of RPF.
LONG-TERM FOLLOW-UP OF LOW-DOSE METHOTREXATE THERAPY IN ONE CASE OF IDIOPATHIC RETROPERITONEAL FIBROSIS / Scavalli, A. S.; Spadaro, Antonio; Riccieri, Valeria; G. P., Ricciuti; Taccari, Egisto; Marini, Mario; Zoppini, Antonio. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - STAMPA. - 14:4(1995), pp. 481-484. [10.1007/bf02207688]