The results of this study indicate that the age-dependent plasma cholesterol increase observed in male Wistar rats is correlated with changes in both the distribution of high-density lipoprotein fractions and the storage of hepatic cholesterol. Specifically, the lipoprotein distribution showed a significant increase in the proportion of HDL1 and a symmetrical decrease in both the HDL2 and HDL3 fractions during the 3 month to 18 month age period. There were no significant changes in the very-low density and low-density lipoprotein fractions. The chemical composition of lipoproteins showed many age-related variations, especially in the proportion of cholesteryl ester and in the distribution of HDL subfractions. A study of fatty acyl composition of the major lipid classes showed that, within cholesteryl ester found in liver, there was an increase in the proportion of saturated fatty acids. Polyunsaturated fatty acids increased in the cholesteryl esters found in high-density lipoproteins of older rats. These observations suggest that the age-dependent accumulation of body cholesterol occurs by a reduced catabolism of HDL, fraction, and modifications in plasma and liver lipids.

Age-related changes in blood and liver lipids of male Wistar rats / Cantafora, A; Masella, R; Pignatelli, E; Verna, Roberto. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 16:(1993), pp. 249-262. [10.1016/0167-4943(93)90036-H]

Age-related changes in blood and liver lipids of male Wistar rats.

VERNA, Roberto
1993

Abstract

The results of this study indicate that the age-dependent plasma cholesterol increase observed in male Wistar rats is correlated with changes in both the distribution of high-density lipoprotein fractions and the storage of hepatic cholesterol. Specifically, the lipoprotein distribution showed a significant increase in the proportion of HDL1 and a symmetrical decrease in both the HDL2 and HDL3 fractions during the 3 month to 18 month age period. There were no significant changes in the very-low density and low-density lipoprotein fractions. The chemical composition of lipoproteins showed many age-related variations, especially in the proportion of cholesteryl ester and in the distribution of HDL subfractions. A study of fatty acyl composition of the major lipid classes showed that, within cholesteryl ester found in liver, there was an increase in the proportion of saturated fatty acids. Polyunsaturated fatty acids increased in the cholesteryl esters found in high-density lipoproteins of older rats. These observations suggest that the age-dependent accumulation of body cholesterol occurs by a reduced catabolism of HDL, fraction, and modifications in plasma and liver lipids.
1993
01 Pubblicazione su rivista::01a Articolo in rivista
Age-related changes in blood and liver lipids of male Wistar rats / Cantafora, A; Masella, R; Pignatelli, E; Verna, Roberto. - In: ARCHIVES OF GERONTOLOGY AND GERIATRICS. - ISSN 0167-4943. - STAMPA. - 16:(1993), pp. 249-262. [10.1016/0167-4943(93)90036-H]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/416928
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact