A family with factor XII severe congenital deficiency is described. Factor XII activity and factor XII antigen were both undetectable in the propositus plasma; levels of FXII:C and FXII:Ag were intermediate in heterozygotes. Plasma prekallikrein activity was low in the propositus, whereas normal levels of antigen could be found, suggesting a defect of kallikrein activation due to factor XII deficiency.
EVALUATION OF THE CLOTTING DEFECT IN A FACTOR XII KINDRED / Chistolini, A.; Mazzucconi, Maria Gabriella; Motta, M.; Solinas, S.; Tirindelli, M. C.; Mariani, M.. - In: LA RICERCA IN CLINICA E IN LABORATORIO. - ISSN 0390-5748. - 15:(1985), pp. 241-245.
EVALUATION OF THE CLOTTING DEFECT IN A FACTOR XII KINDRED
A. Chistolini;MAZZUCCONI, Maria Gabriella;
1985
Abstract
A family with factor XII severe congenital deficiency is described. Factor XII activity and factor XII antigen were both undetectable in the propositus plasma; levels of FXII:C and FXII:Ag were intermediate in heterozygotes. Plasma prekallikrein activity was low in the propositus, whereas normal levels of antigen could be found, suggesting a defect of kallikrein activation due to factor XII deficiency.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
