We report a study undertaken to test the biological effect of intranasal 1-deamino-8-D-arginine vasopressin (DDAVP) and its efficacy in the treatment of bleedings in patients with mild factor VIII deficiency. The biological study was carried out in 20 patients: an increase of factor VIII:C and von Willebrand factor antigen levels was observed after inhalation of DDAVP at average post/pre inhalation ratios of 2.80 and 1.72, respectively. No relevant alterations of fibrinolysis were noted. In fact, we only observed a simultaneous increase of tissue plasminogen activator and plasminogen activator inhibitor, without modification of D-dimer. In 10 cases intranasal DDAVP has been used in the prevention or in the treatment of bleeding complications: no bleedings were observed.
INTRANASAL DDAVP: BIOLOGICAL AND CLINICAL EVALUATION IN MILD F VIII DEFICIENCIES / Chistolini, A.; Dragoni, F.; Ferrari, A.; La Verde, G.; Arcieri, R.; Mohamed, A. E.; Mazzucconi, Maria Gabriella. - In: HAEMOSTASIS. - ISSN 0301-0147. - 21:(1991), pp. 273-277.
INTRANASAL DDAVP: BIOLOGICAL AND CLINICAL EVALUATION IN MILD F VIII DEFICIENCIES
A. Chistolini;MAZZUCCONI, Maria Gabriella
1991
Abstract
We report a study undertaken to test the biological effect of intranasal 1-deamino-8-D-arginine vasopressin (DDAVP) and its efficacy in the treatment of bleedings in patients with mild factor VIII deficiency. The biological study was carried out in 20 patients: an increase of factor VIII:C and von Willebrand factor antigen levels was observed after inhalation of DDAVP at average post/pre inhalation ratios of 2.80 and 1.72, respectively. No relevant alterations of fibrinolysis were noted. In fact, we only observed a simultaneous increase of tissue plasminogen activator and plasminogen activator inhibitor, without modification of D-dimer. In 10 cases intranasal DDAVP has been used in the prevention or in the treatment of bleeding complications: no bleedings were observed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
