The biochemical mechanism of selective heat sensitivity of cancer cells. II. Studies on nucleic acids and protein synthesis

Mondovi', Bruno; Finazzi Agro', A.; Rotilio, G.; Strom, Roberto; Moricca, G.; Rossi Fanelli, A.

doi:10.1016/0014-2964(69)90060-7

The effect of temperature in the range from 38° to 43°C upon incorporation of labeled precursors into DNA, RNA and protein of Novikoff and Morris 5123 hepatoma cells was investigated. A striking inhibition by temperature was found in both kind of tumor cells whereas regenerating liver cells were not affected. The temperature effect was observed also in cells from a human osteosarcoma. Cell free preparations were temperature insensitive. d-glucose added to the incubation mixture caused a marked inhibition. Filipin and ethanol were found to inhibit the incorporation into tumor cells at concentrations which did not significantly affect regenerating liver cells. A possible involvement of membranes in the mechanism of heat sensitivity of tumor cells is suggested. © 1969.

The biochemical mechanism of selective heat sensitivity of cancer cells. II. Studies on nucleic acids and protein synthesis / Mondovi', Bruno; A., Finazzi Agro'; G., Rotilio; Strom, Roberto; G., Moricca; A., Rossi Fanelli. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0014-2964. - STAMPA. - 5:2(1969), pp. 137-146. [10.1016/0014-2964(69)90060-7]

Scheda prodotto non validato

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Titolo:	The biochemical mechanism of selective heat sensitivity of cancer cells. II. Studies on nucleic acids and protein synthesis
Autori:	MONDOVI', Bruno A. Finazzi Agro' G. Rotilio STROM, Roberto G. Moricca A. Rossi Fanelli mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1969
Rivista:	EUROPEAN JOURNAL OF CANCER
Citazione:	The biochemical mechanism of selective heat sensitivity of cancer cells. II. Studies on nucleic acids and protein synthesis / Mondovi', Bruno; A., Finazzi Agro'; G., Rotilio; Strom, Roberto; G., Moricca; A., Rossi Fanelli. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0014-2964. - STAMPA. - 5:2(1969), pp. 137-146. [10.1016/0014-2964(69)90060-7]
Handle:	http://hdl.handle.net/11573/414225
Appartiene alla tipologia:	01a Articolo in rivista

File allegati a questo prodotto

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11573/414225

Citazioni

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Catalogo dei prodotti della ricerca

Scheda prodotto non validato

File allegati a questo prodotto