WE analysed the effects induced by arachidonic acid on voltage-dependent outward currents generated by rat neocortical neurones in culture in the presence of Na+ and Ca2+ channel blockers. These currents, recorded with whole-cell voltage-clamping techniques, were presumably carried by K+ and were characterized by an early transient and a late persistent component. Extracellular application of arachidonic acid (50 muM) enhanced both components of the voltage-dependent K+ response by 15-29% (n > 20 cells). These effects were reversible and not observed when a low dose (50 muM) of indomethacin was present in the bath (n = 7 cells). We conclude that one or more of the arachidonic acid metabolites of the cyclooxygenase pathway might be involved in the modulation of outward currents in neocortical cells in culture.

Arachidonic acid augments potassium outward currents in rat neocortical neurons in culture / Zona, C.; Palma, Eleonora; Pellerin, L.; Avoli, Massimo. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 4:(1993), pp. 359-362. [10.1097/00001756-199304000-00004]

Arachidonic acid augments potassium outward currents in rat neocortical neurons in culture

PALMA, Eleonora;AVOLI, Massimo
1993

Abstract

WE analysed the effects induced by arachidonic acid on voltage-dependent outward currents generated by rat neocortical neurones in culture in the presence of Na+ and Ca2+ channel blockers. These currents, recorded with whole-cell voltage-clamping techniques, were presumably carried by K+ and were characterized by an early transient and a late persistent component. Extracellular application of arachidonic acid (50 muM) enhanced both components of the voltage-dependent K+ response by 15-29% (n > 20 cells). These effects were reversible and not observed when a low dose (50 muM) of indomethacin was present in the bath (n = 7 cells). We conclude that one or more of the arachidonic acid metabolites of the cyclooxygenase pathway might be involved in the modulation of outward currents in neocortical cells in culture.
POTASSIUM CURRENTS, ARACHIDONIC ACID, RAT NEOCORTEX, PATCH CLAMP
01 Pubblicazione su rivista::01a Articolo in rivista
Arachidonic acid augments potassium outward currents in rat neocortical neurons in culture / Zona, C.; Palma, Eleonora; Pellerin, L.; Avoli, Massimo. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 4:(1993), pp. 359-362. [10.1097/00001756-199304000-00004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/41415
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