The effect of a systemic (IP) treatment with 1.0, 3.0 and 9.0 mg/kg U-50,488H (U50), a highly selective kappa-agonist, on spontaneous, nocturnal ingestive behavior of the rat was studied using a microcomputer controlled data acquisition system. The latency to initiate drinking was increased and drinking behavior was suppressed in the first hour after injection in a dose-dependent manner. The consummatory indices of drinking were not affected. After this period of adipsia, a phase of polydipsia, that was probably due to the diuretic effect of U50, was evident. This prophagic effect of U50 was evident only at the dose of 3 mg/kg and was accompanied by an increased duration of feeding episodes but not by a reduced latency to feed. These results suggest that kappa-receptors play a pivotal role in modulating spontaneous drinking in the normally hydrated rat and that this control is mainly exerted on the motivational aspect of drinking

The kappa opioid U-50,488H suppresses the initiation of nocturnal spontaneous drinking in normally hydrated rats / Badiani, Aldo; Stewart, J.. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 106:(1992), pp. 463-473. [10.1007/BF02244816]

The kappa opioid U-50,488H suppresses the initiation of nocturnal spontaneous drinking in normally hydrated rats

BADIANI, Aldo;
1992

Abstract

The effect of a systemic (IP) treatment with 1.0, 3.0 and 9.0 mg/kg U-50,488H (U50), a highly selective kappa-agonist, on spontaneous, nocturnal ingestive behavior of the rat was studied using a microcomputer controlled data acquisition system. The latency to initiate drinking was increased and drinking behavior was suppressed in the first hour after injection in a dose-dependent manner. The consummatory indices of drinking were not affected. After this period of adipsia, a phase of polydipsia, that was probably due to the diuretic effect of U50, was evident. This prophagic effect of U50 was evident only at the dose of 3 mg/kg and was accompanied by an increased duration of feeding episodes but not by a reduced latency to feed. These results suggest that kappa-receptors play a pivotal role in modulating spontaneous drinking in the normally hydrated rat and that this control is mainly exerted on the motivational aspect of drinking
1992
01 Pubblicazione su rivista::01a Articolo in rivista
The kappa opioid U-50,488H suppresses the initiation of nocturnal spontaneous drinking in normally hydrated rats / Badiani, Aldo; Stewart, J.. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 106:(1992), pp. 463-473. [10.1007/BF02244816]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/41314
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