The analgesic response (tail-flick latency) induced by the muscarinic cholinergic agonist oxotremorine was investigated in DBA/2 mice exposed to acute (a single 2 h session) and chronic (2 h once daily for 10 days) restraint stress. While a single exposure to stress did not influence the antinociceptive effects of the cholinergic agonist, chronic stress induced a clear-cut reduction of the oxotremorine-induced analgesia. The results show an involvement of cholinergic mechanisms in the adaptive modulation of nociception after chronic stressful events.
REDUCTION OF OXOTREMORINE-INDUCED ANALGESIA AFTER CHRONIC BUT NOT ACUTE RESTRAINT STRESS / Badiani, Aldo; Flaminia, Pavone. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 104:1(1991), pp. 57-61. [10.1007/bf02244554]
REDUCTION OF OXOTREMORINE-INDUCED ANALGESIA AFTER CHRONIC BUT NOT ACUTE RESTRAINT STRESS
BADIANI, Aldo;
1991
Abstract
The analgesic response (tail-flick latency) induced by the muscarinic cholinergic agonist oxotremorine was investigated in DBA/2 mice exposed to acute (a single 2 h session) and chronic (2 h once daily for 10 days) restraint stress. While a single exposure to stress did not influence the antinociceptive effects of the cholinergic agonist, chronic stress induced a clear-cut reduction of the oxotremorine-induced analgesia. The results show an involvement of cholinergic mechanisms in the adaptive modulation of nociception after chronic stressful events.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
