Paraventricular (PVN) concentrations of neuropeptide Y (NPY), serotonin (5-HT) and dopamine (DA) in anorectic tumor-bearing (TB) rats were measured before and after tumor resection. At onset of anorexia in TB versus non-tumor bearing (NTB) Controls 5-HT increased from 12.19±0.49pg/μg to 14.89±0.81pg/μg (P<0.05) while DA and NPY decreased from 7.34±0.42pg/μg to 4.97±0.56pg/μg and 23.47±4.27pg/ μg to 13.64±1.44pg/μg, respectively (P<0.05). After tumor resection, these neuromediators normalized when compared to sham-operated NTB rats. NTB pair-fed Controls were also studied. We conclude that the increased 5-HT and the decreased DA and NPY concentrations in PVN are associated with cancer anorexia and that the NPY food stimulatory effect is linked to serotoninergic and dopaminergic systems in hypothalamus. © 2004 Elsevier Inc. All rights reserved.
Tumor anorexia: Effects on neuropeptide Y and monoamines in paraventricular nucleus / Michael M., Meguid; Eduardo J. B., Ramos; Laviano, Alessandro; Madhu, Varma; Tomoi, Sato; Chung, Chen; Yong, Qi; Undurti N., Das. - In: PEPTIDES. - ISSN 0196-9781. - 25:2(2004), pp. 261-266. [10.1016/j.peptides.2004.01.012]
Tumor anorexia: Effects on neuropeptide Y and monoamines in paraventricular nucleus
LAVIANO, Alessandro;
2004
Abstract
Paraventricular (PVN) concentrations of neuropeptide Y (NPY), serotonin (5-HT) and dopamine (DA) in anorectic tumor-bearing (TB) rats were measured before and after tumor resection. At onset of anorexia in TB versus non-tumor bearing (NTB) Controls 5-HT increased from 12.19±0.49pg/μg to 14.89±0.81pg/μg (P<0.05) while DA and NPY decreased from 7.34±0.42pg/μg to 4.97±0.56pg/μg and 23.47±4.27pg/ μg to 13.64±1.44pg/μg, respectively (P<0.05). After tumor resection, these neuromediators normalized when compared to sham-operated NTB rats. NTB pair-fed Controls were also studied. We conclude that the increased 5-HT and the decreased DA and NPY concentrations in PVN are associated with cancer anorexia and that the NPY food stimulatory effect is linked to serotoninergic and dopaminergic systems in hypothalamus. © 2004 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
