Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies.
New models for cancer research: human cancer stem cell xenografts / Baiocchi, Marta; Mauro, Biffoni; Lucia Ricci Vitiani, ; Pilozzi, Emanuela; Ruggero De Maria,. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 10:4(2010), pp. 380-384. [10.1016/j.coph.2010.05.002]
New models for cancer research: human cancer stem cell xenografts
Marta Baiocchi;PILOZZI, Emanuela;
2010
Abstract
Human cancer stem cells represent promising tools for new approaches to pathway-targeted drug discovery and preclinical screening. Because of their distinctive capability to recapitulate the development of the original tumors in vivo, the study of human cancer stem cells (CSCs) largely relies on models of xenograft transplantation into immunodeficient mice. In this frame, immunity and microenvironment-related issues need careful consideration. Here we shortly revise present knowledge on xenograft-related aspects of human CSCs studies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
