Glycosphingolipids are essential components of plasma membrane and act as antigens, mediators of cell adhesion, and modulators of signal transduction. Following activation of the Fas receptor, gangliosides are recuited in various intracellular compartments. We have evaluated whether the pro-apoptotic anti-CD95 antibody induces a nuclear localization of GD3 in HUT-78 cells. Our data shows that GD3 translocation from cytosol to nuclei is strongly correlated to concomitant rapid phosphorylation of histone H1 shortly after induction of apoptosis. This work advances the hypothesis that GD3 induces a post-translational modification of histone H1 thus influencing the apoptosis process through transcriptional activation/repression of specific genes. (c) 2008 Elsevier Inc. All rights reserved.

GD3 nuclear localization after apoptosis induction in HUT-78 cells / Tempera, Italo; Buchetti, Barbara; Emanuela, Lococo; Gradini, Roberto; Annalisa, Mastronardi; Mascellino, Maria Teresa; Sale, Patrizio; Mosca, Luciana; D'Erme, Maria; Lenti, Luisa. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 368:3(2008), pp. 495-500. [10.1016/j.bbrc.2007.12.196]

GD3 nuclear localization after apoptosis induction in HUT-78 cells

TEMPERA, Italo;BUCHETTI, Barbara;GRADINI, Roberto;MASCELLINO, Maria Teresa;SALE, PATRIZIO;MOSCA, Luciana;D'ERME, Maria;LENTI, Luisa
2008

Abstract

Glycosphingolipids are essential components of plasma membrane and act as antigens, mediators of cell adhesion, and modulators of signal transduction. Following activation of the Fas receptor, gangliosides are recuited in various intracellular compartments. We have evaluated whether the pro-apoptotic anti-CD95 antibody induces a nuclear localization of GD3 in HUT-78 cells. Our data shows that GD3 translocation from cytosol to nuclei is strongly correlated to concomitant rapid phosphorylation of histone H1 shortly after induction of apoptosis. This work advances the hypothesis that GD3 induces a post-translational modification of histone H1 thus influencing the apoptosis process through transcriptional activation/repression of specific genes. (c) 2008 Elsevier Inc. All rights reserved.
2008
apoptosis; gangliosides; gd3; hut-78
01 Pubblicazione su rivista::01a Articolo in rivista
GD3 nuclear localization after apoptosis induction in HUT-78 cells / Tempera, Italo; Buchetti, Barbara; Emanuela, Lococo; Gradini, Roberto; Annalisa, Mastronardi; Mascellino, Maria Teresa; Sale, Patrizio; Mosca, Luciana; D'Erme, Maria; Lenti, Luisa. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 368:3(2008), pp. 495-500. [10.1016/j.bbrc.2007.12.196]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/41215
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