EPD is a method of preventive immunotherapy which employs b-glucuronidase as a biological response modifier. Plasma IL-6 and IL-10 were measured before a single injection of EPD, 24 hours later and 15 days after in a group of 17 children suffering from grass pollen asthma. 17 normal untreated children were used as controls. Although the study was conducted before the grass pollen season when the allergic children were free of symptoms, their plasma IL-6 and IL-10 were significantly elevated before the injection of EPD. 24 hours after treatment the plasma IL-10 had increased significantly and there was also a slight rise in IL-6. 15 days after treatment IL-6 had fallen to normal but IL-10 was still elevated. These findings suggest antigen-specific and non-specific mechanisms by which EPD may produce clinical improvement.

Effect of preseasonal enzyme potentiated desensitisation (EPD) on plasma-IL-6 and IL-10 of grass pollen-sensitive asthmatic children / Ippoliti, Flora; Ragno, V; DEL NERO, Angelo; Mcewen, Lm; Mcewen, H; Businco, Luisa. - In: ALLERGIE ET IMMUNOLOGIE. - ISSN 0397-9148. - STAMPA. - 5:29(1997), pp. 120-125.

Effect of preseasonal enzyme potentiated desensitisation (EPD) on plasma-IL-6 and IL-10 of grass pollen-sensitive asthmatic children.

IPPOLITI, Flora;DEL NERO, Angelo;BUSINCO, Luisa
1997

Abstract

EPD is a method of preventive immunotherapy which employs b-glucuronidase as a biological response modifier. Plasma IL-6 and IL-10 were measured before a single injection of EPD, 24 hours later and 15 days after in a group of 17 children suffering from grass pollen asthma. 17 normal untreated children were used as controls. Although the study was conducted before the grass pollen season when the allergic children were free of symptoms, their plasma IL-6 and IL-10 were significantly elevated before the injection of EPD. 24 hours after treatment the plasma IL-10 had increased significantly and there was also a slight rise in IL-6. 15 days after treatment IL-6 had fallen to normal but IL-10 was still elevated. These findings suggest antigen-specific and non-specific mechanisms by which EPD may produce clinical improvement.
EPD; plasma-IL-6 and IL-10; of grass pollen-sensitive asthmatic children
01 Pubblicazione su rivista::01a Articolo in rivista
Effect of preseasonal enzyme potentiated desensitisation (EPD) on plasma-IL-6 and IL-10 of grass pollen-sensitive asthmatic children / Ippoliti, Flora; Ragno, V; DEL NERO, Angelo; Mcewen, Lm; Mcewen, H; Businco, Luisa. - In: ALLERGIE ET IMMUNOLOGIE. - ISSN 0397-9148. - STAMPA. - 5:29(1997), pp. 120-125.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/412080
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