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EnglishDespite their histological resemblance to colorectal adenocarcinoma, there is little information on the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinoma (ITACs). The aim of this paper is to evaluate the possible role of TP53 and Bcl-2 gene defects in ITAC by investigating the immunohistochemical expression of TP53 and Bcl-2 gene products in a group of ethmoidal ITACs associated with occupational exposure. A retrospective study on 15 patients with pathological diagnosis of primary ethmoidal ITAC was conducted. Representative formalin-fixed, paraffin wax-embedded block from each case was selected for immunohistochemical studies using the antibodies against p53 and Bcl-2. Clinical-pathological data were also correlated with the staining results. The results of immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of p53 and Bcl-2 expressing cells in comparison to well-differentiated cases. No correlation was found with other clinico-pathological parameters, including T, stage and relapses. The relationship between up-regulation of p53 and Bcl-2 and poorly differentiated ethmoidal adenocarcinoma suggests a role of these genes, in combination with additional genetic events, in the pathogenesis of ITAC. Copyright © by BIOLIFE, s.a.s.
p53 and Bcl-2 over-expression inversely correlates with histological differentiation in occupational ethmoidal intestinal-type sinonasal adenocarcinoma / M., Re; Magliulo, Giuseppe; P., Tarchini; V., Mallardi; C., Rubini; A., Santarelli; L., Lo Muzio. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 24:3(2011), pp. 603-609.
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| Titolo: | p53 and Bcl-2 over-expression inversely correlates with histological differentiation in occupational ethmoidal intestinal-type sinonasal adenocarcinoma | |
| Autori: | ||
| Data di pubblicazione: | 2011 | |
| Rivista: | ||
| Citazione: | p53 and Bcl-2 over-expression inversely correlates with histological differentiation in occupational ethmoidal intestinal-type sinonasal adenocarcinoma / M., Re; Magliulo, Giuseppe; P., Tarchini; V., Mallardi; C., Rubini; A., Santarelli; L., Lo Muzio. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 24:3(2011), pp. 603-609. | |
| Handle: | http://hdl.handle.net/11573/411476 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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