To study the pattern of thyroglobulin (Tg) serum concentrations in the first days of life, Tg, TSH, T 3, and T 4 were measured in both maternal and cord blood at delivery and 1, 6, 12, 24, 48, 72, and 96 h after birth in 16 newborns. Tg levels at birth were higher in cord blood than in maternal blood. After birth, a prolonged Tg rise occurred. The increased levels became significant at 6 h and were maintained throughout the study. Tg levels were not correlated with serum levels of T 3, T 4, and TSH. We conclude that either a reduced Tg MCR or an increased thyroidal secretion of Tg after endogenous TSH stimulation in the newborn is a possible explanation for the elevated Tg levels occurring during the first days of life.
Serum thyroglobulin levels in the newborn / Vincenzo, Pezzino; Filetti, Sebastiano; Antonio, Belfiore; Silvio, Proto; Giuseppe, Donzelli; Riccardo, Vigneri. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - STAMPA. - 52:2(1981), pp. 364-366. [10.1210/jcem-52-2-364]
Serum thyroglobulin levels in the newborn
FILETTI, SEBASTIANO;
1981
Abstract
To study the pattern of thyroglobulin (Tg) serum concentrations in the first days of life, Tg, TSH, T 3, and T 4 were measured in both maternal and cord blood at delivery and 1, 6, 12, 24, 48, 72, and 96 h after birth in 16 newborns. Tg levels at birth were higher in cord blood than in maternal blood. After birth, a prolonged Tg rise occurred. The increased levels became significant at 6 h and were maintained throughout the study. Tg levels were not correlated with serum levels of T 3, T 4, and TSH. We conclude that either a reduced Tg MCR or an increased thyroidal secretion of Tg after endogenous TSH stimulation in the newborn is a possible explanation for the elevated Tg levels occurring during the first days of life.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
