These studies were undertaken to examine, in the thyroid, whether N protein is specifically ADP-rybosylated by TSH. In addition, the functional activity of the N protein, as well as of the adenylate cyclase catalytic unit (C) was tested in membranes from thyroid cells desensitized to TSH. The data obtained suggest that N protein ADP-ribosylation is not responsible for TSH desensitization, and help localize the 'defect' in TSH desensitization to TSH receptor (R) function, or to R-N interaction.

Studies on the desensitization of the cyclic AMP response to the thyrotropin in thyroid tissue / B., Rapoport; Filetti, Sebastiano; N., Takai; P., Seto. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 146:1(1982), pp. 23-27. [10.1016/0014-5793(82)80697-2]

Studies on the desensitization of the cyclic AMP response to the thyrotropin in thyroid tissue

FILETTI, SEBASTIANO;
1982

Abstract

These studies were undertaken to examine, in the thyroid, whether N protein is specifically ADP-rybosylated by TSH. In addition, the functional activity of the N protein, as well as of the adenylate cyclase catalytic unit (C) was tested in membranes from thyroid cells desensitized to TSH. The data obtained suggest that N protein ADP-ribosylation is not responsible for TSH desensitization, and help localize the 'defect' in TSH desensitization to TSH receptor (R) function, or to R-N interaction.
1982
01 Pubblicazione su rivista::01a Articolo in rivista
Studies on the desensitization of the cyclic AMP response to the thyrotropin in thyroid tissue / B., Rapoport; Filetti, Sebastiano; N., Takai; P., Seto. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 146:1(1982), pp. 23-27. [10.1016/0014-5793(82)80697-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/411068
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