The activity of thymus-dependent serum factor SF was significantly lower in 18 children wit Down's syndrome (DS) than in 14 matched controls. The percentage of circulating T lymphocytes forming E-rosettes was also low in DS. Together with the previous finding of immature of T lymphocytes in peripheral blood, the present data suggest that the basic immune defect of DS is failure in differentiation of peripheral post-thymic precursors to fully immunocompetent T lymphocytes resulting from lack of thymic hormonal factors.
Immunodeficiency in Down's syndrome: low levels of serum thymic factor in trisomic children / Duse, Marzia; M. A., Brugo; A., Martini; C., Tassi; C., Ferrario; A. G., Ugazio. - In: THYMUS. - ISSN 0165-6090. - STAMPA. - 2:3(1980), pp. 127-131.
Immunodeficiency in Down's syndrome: low levels of serum thymic factor in trisomic children.
DUSE, MARZIA;
1980
Abstract
The activity of thymus-dependent serum factor SF was significantly lower in 18 children wit Down's syndrome (DS) than in 14 matched controls. The percentage of circulating T lymphocytes forming E-rosettes was also low in DS. Together with the previous finding of immature of T lymphocytes in peripheral blood, the present data suggest that the basic immune defect of DS is failure in differentiation of peripheral post-thymic precursors to fully immunocompetent T lymphocytes resulting from lack of thymic hormonal factors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
