The pathogenesis of vascular damage in Behçet's disease (BD) is still unknown. We investigated anticardiolipin antibodies (AC) in a genetically homogeneous group of Italian patients with BD and retinal vasculitis. In a subset, we examined the level of factor VIII-related antigen and antiendothelial cell antibodies (AECA). We found a high prevalence of AC; AECA were not found in most of our patients. Only three patients had raised levels of factor VIII-related antigen, all of whom had systemic involvement. We believe BD may be considered as a vasculitis of unknown origin in which several and different pathogenetic factors may play a role.
Markers of vascular injury in Behçet's disease associated with retinal vasculitis / Pivetti, Paola; R., Priori; G., Catarinelli; P. L., Meroni; A. B., Federici; M., Abdulaziz; Falco, Mirella; Valesini, Guido. - In: ANNALS OF OPHTHALMOLOGY. - ISSN 0003-4886. - 24:11(1992), pp. 411-414.
Markers of vascular injury in Behçet's disease associated with retinal vasculitis.
PIVETTI, Paola;FALCO, Mirella;VALESINI, Guido
1992
Abstract
The pathogenesis of vascular damage in Behçet's disease (BD) is still unknown. We investigated anticardiolipin antibodies (AC) in a genetically homogeneous group of Italian patients with BD and retinal vasculitis. In a subset, we examined the level of factor VIII-related antigen and antiendothelial cell antibodies (AECA). We found a high prevalence of AC; AECA were not found in most of our patients. Only three patients had raised levels of factor VIII-related antigen, all of whom had systemic involvement. We believe BD may be considered as a vasculitis of unknown origin in which several and different pathogenetic factors may play a role.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
