The main objective of this study is to evaluate the effect of immunomodulatory agents (IMAs) (Interferon-Beta, Glatiramer Acetate) in a large cohort of multiple sclerosis (MS) patients with disease onset in childhood or adolescence, treated before 16 years of age, after a long-term follow-up. A total of 130 patients were identified, 77 were treated with Avonex, 39 with Rebif/Betaferon, 14 with Copaxone. After a mean (SD) treatment duration of 53.6 ± 27.0, 59.9 ± 39.5 and 74.6 ± 35.5 months, respectively, the relapse rate decreased significantly. The final EDSS score was unchanged with respect to the initial score. Similar results were also observed in subjects who continued a long-term follow-up after they were included in an observational study in 2004, and in subjects who were treated before 12 years of age. The frequency of clinical and laboratory adverse events was similar to that observed in adult patients. To conclude, IMAs were effective and well tolerated in paediatric patients with MS. © Springer-Verlag 2009.

Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: The Italian experience / Angelo, Ghezzi; Maria Pia, Amato; Pietro, Annovazzi; Marco, Capobianco; Paolo, Gallo; Loredana La, Mantia; Maria Giovanna, Marrosu; Vittorio, Martinelli; Nicoletta, Milani; Lucia, Moiola; Francesco, Patti; Pozzilli, Carlo; Maria, Trojano; Mauro, Zaffaroni; Giancarlo, Comi; Items Immunomodulatory Treatment Of Early Onset M. S., Group. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 30:3(2009), pp. 193-199. [10.1007/s10072-009-0083-1]

Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: The Italian experience

POZZILLI, Carlo;
2009

Abstract

The main objective of this study is to evaluate the effect of immunomodulatory agents (IMAs) (Interferon-Beta, Glatiramer Acetate) in a large cohort of multiple sclerosis (MS) patients with disease onset in childhood or adolescence, treated before 16 years of age, after a long-term follow-up. A total of 130 patients were identified, 77 were treated with Avonex, 39 with Rebif/Betaferon, 14 with Copaxone. After a mean (SD) treatment duration of 53.6 ± 27.0, 59.9 ± 39.5 and 74.6 ± 35.5 months, respectively, the relapse rate decreased significantly. The final EDSS score was unchanged with respect to the initial score. Similar results were also observed in subjects who continued a long-term follow-up after they were included in an observational study in 2004, and in subjects who were treated before 12 years of age. The frequency of clinical and laboratory adverse events was similar to that observed in adult patients. To conclude, IMAs were effective and well tolerated in paediatric patients with MS. © Springer-Verlag 2009.
2009
adolescence; childhood; glatiramer acetate; immunomodulatory agents; interferon-beta; multiple sclerosis; paediatric multiple sclerosis
01 Pubblicazione su rivista::01a Articolo in rivista
Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: The Italian experience / Angelo, Ghezzi; Maria Pia, Amato; Pietro, Annovazzi; Marco, Capobianco; Paolo, Gallo; Loredana La, Mantia; Maria Giovanna, Marrosu; Vittorio, Martinelli; Nicoletta, Milani; Lucia, Moiola; Francesco, Patti; Pozzilli, Carlo; Maria, Trojano; Mauro, Zaffaroni; Giancarlo, Comi; Items Immunomodulatory Treatment Of Early Onset M. S., Group. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 30:3(2009), pp. 193-199. [10.1007/s10072-009-0083-1]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/41010
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 64
  • ???jsp.display-item.citation.isi??? 51
social impact