We report the case of a 38-year-old man, previously treated for Hodgkin's disease (HD) with chemo-radiotherapy who, 10 years later, developed a Burkitt lymphoma (BL) as a tumour mass of the ascendent colon and regional lymph nodes and, subsequently, on leukaemic bone-marrow cells, on the basis of histological, immunological (B phenotype, IgM-lambda) and cytogenetic, translocation t(8;14) features. The patient died a few days later; at autopsy no evidence of HD was found. This is the 2nd case of BL developing after HD so far described. The relationship between the 2 diseases is discussed and the importance of the immunodepression in the pathogenesis of the secondary Burkitt lymphoma is emphasized.

A case of Burkitt lymphoma-L3 ALL with t(8;14)translocation, developed 10 years after Hodgkin's disease / Mandelli, Franco; Martelli, Maurizio; Cimino, Giuseppe; Alimena, Giuliana; Anselmo, Anna Paola; De Cuia, Mr; Gastaldi, R; Arcese, W; Papa, G.. - In: SCANDINAVIAN JOURNAL OF HAEMATOLOGY. - ISSN 0036-553X. - 34(1985), pp. 97-100.

A case of Burkitt lymphoma-L3 ALL with t(8;14)translocation, developed 10 years after Hodgkin's disease.

MANDELLI, Franco;MARTELLI, Maurizio;CIMINO, Giuseppe;ALIMENA, Giuliana;ANSELMO, Anna Paola;
1985

Abstract

We report the case of a 38-year-old man, previously treated for Hodgkin's disease (HD) with chemo-radiotherapy who, 10 years later, developed a Burkitt lymphoma (BL) as a tumour mass of the ascendent colon and regional lymph nodes and, subsequently, on leukaemic bone-marrow cells, on the basis of histological, immunological (B phenotype, IgM-lambda) and cytogenetic, translocation t(8;14) features. The patient died a few days later; at autopsy no evidence of HD was found. This is the 2nd case of BL developing after HD so far described. The relationship between the 2 diseases is discussed and the importance of the immunodepression in the pathogenesis of the secondary Burkitt lymphoma is emphasized.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/409955
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