Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of clinical attacks. Chronic administrations of Cs significantly diminish the formation of T1 hypointense lesions and the progression of brain atrophy. As for patients with secondary progressive MS treatment with Cs delays the time to onset of sustained disability. Finally the association between methylprednisolone and interferon beta (IFNβ) leads the recovery of active lesions at greater extent and reduces the formation of neutralizing antibodies (NABs) against IFNβ in patients with RRMS. © 2004 Elsevier B.V. All rights reserved.
Corticosteroids treatment / Pozzilli, Carlo; Fabiana, Marinelli; Romano, Silvia; Francesca, Bagnato. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 223:1(2004), pp. 47-51. [10.1016/j.jns.2004.04.019]
Corticosteroids treatment
POZZILLI, Carlo;ROMANO, SILVIA;
2004
Abstract
Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of clinical attacks. Chronic administrations of Cs significantly diminish the formation of T1 hypointense lesions and the progression of brain atrophy. As for patients with secondary progressive MS treatment with Cs delays the time to onset of sustained disability. Finally the association between methylprednisolone and interferon beta (IFNβ) leads the recovery of active lesions at greater extent and reduces the formation of neutralizing antibodies (NABs) against IFNβ in patients with RRMS. © 2004 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
