The karyotypes of 74 patients with Ph-positive chronic myeloid leukemia submitted to bone marrow transplantation collected from nine institutions were studied serially before and after transplantation. In 13 cases sporadic Ph-positive metaphases were detected without signs of relapsing disease at various intervals after transplantation. These data indicate that the leukemic clone may not be completely suppressed by the conditioning treatment and that other biological mechanisms may be involved in destroying this clone or controlling its expansion.
Chromosomes studies in patiens with Philadelphia chromosome positive chronic myeloid leukemia submitted to bone marrow transplantation. Results of an European cooperative study / Zaccaria, A; Rosti, G; Testoni, N; Alimena, Giuliana; Arcese, W; Bandini, G; Boogaerts, M; Carbonell, F; Ferrant, A; Filippetti, A; Frassoni, F; Gahrton, G; Haas, Oa; Iacone, A; Mecucci, C; Michaux, Jl; Palka, G; Pollak, C; Rosetti, A; Ricci, P; Schmeizer, T; Sessarego, M; Valenti, S; van den Beghe, H; Tura, S.. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - 26:(1987), pp. 5-13. [10.1016/0165-4608(87)90128-2]
Chromosomes studies in patiens with Philadelphia chromosome positive chronic myeloid leukemia submitted to bone marrow transplantation. Results of an European cooperative study.
ALIMENA, Giuliana;
1987
Abstract
The karyotypes of 74 patients with Ph-positive chronic myeloid leukemia submitted to bone marrow transplantation collected from nine institutions were studied serially before and after transplantation. In 13 cases sporadic Ph-positive metaphases were detected without signs of relapsing disease at various intervals after transplantation. These data indicate that the leukemic clone may not be completely suppressed by the conditioning treatment and that other biological mechanisms may be involved in destroying this clone or controlling its expansion.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
