To evaluate further the prognostic significance of karyotype at diagnosis of acute myelogenous leukemia (AML), we have made a follow-up study of 711 patients who were diagnosed between January 1, 1980, and March 31, 1982, and who were originally reported by the Fourth International Workshop on Chromosomes in Leukemia (4IWCL). Three different chromosomal classifications were evaluated, including presence of normal and abnormal metaphases (NN-AN-AA classification), a modification of the Chicago classification, and a complexity classification. All three chromosomal classifications were shown to correlate significantly with outcome in patients with de novo AML. Furthermore, the NN-AN-AA classification and the complexity classification had independent prognostic significance when age, sex, and FAB morphology were also considered in multivariate analyses of survival. These data provide further evidence that karyotype is an important factor in predicting the outcome of patients with AML.
The clinical significance of karyotype in acute myelogenous leukemia: A follow-up report from the Sixth International Workshop on Chromosomes in Leukemia / Arthur, Dc; Berger, R; Golomb, Hm; Swansbury, J; Reeves, Br; Alimena, Giuliana; van den Berghe, H; Bloomfield, Cd; de la Chapelle, A; Dewald, Gw; Garson, Om; Hagemeijer, A; Kaneko, Y; Mitelman, F; Pierre, Rv; Ruutu, T; Sakurai, M; Lawler, Sd; Rowley, J. D.. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - 40:(1989), pp. 203-210.
The clinical significance of karyotype in acute myelogenous leukemia: A follow-up report from the Sixth International Workshop on Chromosomes in Leukemia.
ALIMENA, Giuliana;
1989
Abstract
To evaluate further the prognostic significance of karyotype at diagnosis of acute myelogenous leukemia (AML), we have made a follow-up study of 711 patients who were diagnosed between January 1, 1980, and March 31, 1982, and who were originally reported by the Fourth International Workshop on Chromosomes in Leukemia (4IWCL). Three different chromosomal classifications were evaluated, including presence of normal and abnormal metaphases (NN-AN-AA classification), a modification of the Chicago classification, and a complexity classification. All three chromosomal classifications were shown to correlate significantly with outcome in patients with de novo AML. Furthermore, the NN-AN-AA classification and the complexity classification had independent prognostic significance when age, sex, and FAB morphology were also considered in multivariate analyses of survival. These data provide further evidence that karyotype is an important factor in predicting the outcome of patients with AML.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
