We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germline configuration. T cell receptor beta and gamma chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.

Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T-cell features / Lo Coco, F; Francia di Celle, P; Alimena, Giuliana; De Rossi, G; Gastaldi, R; Saglio, G; Foa, Roberto. - In: LEUKEMIA. - ISSN 0887-6924. - 3:(1989), pp. -79.

Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T-cell features.

ALIMENA, Giuliana;FOA, Roberto
1989

Abstract

We describe a case of ALL with the t(4;11) (q21;q23) translocation in which both surface markers and molecular analyses suggest an unusual early T cell involvement. While the morphologic and cytochemical studies showed an undifferentiated pattern, immunophenotypic data were suggestive of a very immature cell population which stained only for TdT and CD7. Moreover, in contrast to previous reports but in agreement with the immunologic findings, the IgH gene region retained a germline configuration. T cell receptor beta and gamma chain gene loci also showed a germline pattern, in accordance with the expansion of immature CD7+, TdT+ T cells.
1989
01 Pubblicazione su rivista::01a Articolo in rivista
Acute lymphoblastic leukemia with the 4;11 translocation exhibiting early T-cell features / Lo Coco, F; Francia di Celle, P; Alimena, Giuliana; De Rossi, G; Gastaldi, R; Saglio, G; Foa, Roberto. - In: LEUKEMIA. - ISSN 0887-6924. - 3:(1989), pp. -79.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/409262
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 7
social impact