TSH data from the congenital hypothyroidism screening program were analyzed in a mild to moderate iodine deficiency region. Neonatal TSH levels were measured at day 4-5 of life in 22,384 infants (99% coverage; 51.1% males, 48.9% females). The cut off TSH value for recall was established at 20 mu Ul/ml whole blood. TSH values >20 mu Ul/ml were excluded from further analysis of the data. The frequency distribution analysis showed that the median neonatal TSH level was 2 mu Ul/ml and the mode (28% of newborns) corresponded to neonatal TSH values <1 mu Ul/ml, TSH levels above 5 mu Ul/ml were observed in 14.4% children and the 97% cut off was 11 mu Ul/ml. When examined in relation to the areas of newborn origin, the individual 97% cut off values varied from 8 to 14 mu Ul/ml. Accordingly, the frequency of TSH levels above the 97% cut off value calculated for the entire newborn series (>11 mu Ul/ml) ranged from 2.1% to 4.6%, A significant correlation was found between the frequency of neonatal TSH levels >11 mu Ul/ml and both goiter prevalence (r(2) = 0.88; p = 0.0019) and median urinary iodine excretion (r(2) = 0.86, p = 0.0077) observed in those areas for which epidemiological data were available (n = 7), The results indicate that neonatal TSH data from the congenital hypothyroidism screening programs can be used for monitoring mild to moderate iodine deficiency regions, (C) 1997, Editrice Kurtis.
The statistical analysis of neonatal TSH results from congenital hypothyroidism screening programs provides a useful tool for the characterization of moderate iodine deficiency regions / G., Costante; L., Grasso; O., Ludovico; M. F., Marasco; M., Nocera; E., Schifino; L., Rivalta; C., Capula; R., Chiarella; Filetti, Sebastiano; G., Parlato. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 20:5(1997), pp. 251-256.
The statistical analysis of neonatal TSH results from congenital hypothyroidism screening programs provides a useful tool for the characterization of moderate iodine deficiency regions
FILETTI, SEBASTIANO;
1997
Abstract
TSH data from the congenital hypothyroidism screening program were analyzed in a mild to moderate iodine deficiency region. Neonatal TSH levels were measured at day 4-5 of life in 22,384 infants (99% coverage; 51.1% males, 48.9% females). The cut off TSH value for recall was established at 20 mu Ul/ml whole blood. TSH values >20 mu Ul/ml were excluded from further analysis of the data. The frequency distribution analysis showed that the median neonatal TSH level was 2 mu Ul/ml and the mode (28% of newborns) corresponded to neonatal TSH values <1 mu Ul/ml, TSH levels above 5 mu Ul/ml were observed in 14.4% children and the 97% cut off was 11 mu Ul/ml. When examined in relation to the areas of newborn origin, the individual 97% cut off values varied from 8 to 14 mu Ul/ml. Accordingly, the frequency of TSH levels above the 97% cut off value calculated for the entire newborn series (>11 mu Ul/ml) ranged from 2.1% to 4.6%, A significant correlation was found between the frequency of neonatal TSH levels >11 mu Ul/ml and both goiter prevalence (r(2) = 0.88; p = 0.0019) and median urinary iodine excretion (r(2) = 0.86, p = 0.0077) observed in those areas for which epidemiological data were available (n = 7), The results indicate that neonatal TSH data from the congenital hypothyroidism screening programs can be used for monitoring mild to moderate iodine deficiency regions, (C) 1997, Editrice Kurtis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.