The effects of morphine, given alone and in combination with chlordiazepoxide, have been investigated in the inbredstrains of mice DBA/2J (DBA) and C57BL/6J (C57). Morphine increased the spontaneous locomotoractivity only in the C57 strain, whereas no effect was found when it was administered to the DBA strain. Chlordiazepoxide, at dose levels which did not influence the locomotion, significantly increased the locomotoractivity of DBA mice when given in combination with morphine. Conversely, chlordiazepoxide, at each dose tested in the present study, did not enhance the stimulation of locomotoractivity elicited by morphine in the C57 strain.
Effects of morphine and chlordiazepoxide on locomotor activity in two inbred strains of mice / Cuomo, Vincenzo; I., Cortese; G., Racagni. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - STAMPA. - 13:1(1981), pp. 87-93.
Effects of morphine and chlordiazepoxide on locomotor activity in two inbred strains of mice
CUOMO, VINCENZO;
1981
Abstract
The effects of morphine, given alone and in combination with chlordiazepoxide, have been investigated in the inbredstrains of mice DBA/2J (DBA) and C57BL/6J (C57). Morphine increased the spontaneous locomotoractivity only in the C57 strain, whereas no effect was found when it was administered to the DBA strain. Chlordiazepoxide, at dose levels which did not influence the locomotion, significantly increased the locomotoractivity of DBA mice when given in combination with morphine. Conversely, chlordiazepoxide, at each dose tested in the present study, did not enhance the stimulation of locomotoractivity elicited by morphine in the C57 strain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
