Morphine and chlordiazepoxide were tested in the inbred strains of mice DBA/2J (DBA) and C57BL/6J (C57), subjected to three daily 50-trial avoidance sessions in the shuttle-box. The DBA strain reached higher avoidance levels in comparison to the C57 strain after the administration of saline. Morphine facilitated avoidance responding in the C57 strain but not in DBA mice. An improvement in avoidance behaviour was observed following the administration of chlordiazepoxide in both strains of mice. Some favourable effects were obtained in DBA mice by combining morphine with chlordiazepoxide, whereas no interaction between these drugs was found in the C57 strain.
Effects of morphine and chlordiazepoxide on avoidance behaviour in two inbred strains of mice / Cuomo, Vincenzo; I., Cortese; G., Racagni. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - STAMPA. - 20:3(1981), pp. 301-304. [10.1016/0028-3908(81)90138-6]
Effects of morphine and chlordiazepoxide on avoidance behaviour in two inbred strains of mice
CUOMO, VINCENZO;
1981
Abstract
Morphine and chlordiazepoxide were tested in the inbred strains of mice DBA/2J (DBA) and C57BL/6J (C57), subjected to three daily 50-trial avoidance sessions in the shuttle-box. The DBA strain reached higher avoidance levels in comparison to the C57 strain after the administration of saline. Morphine facilitated avoidance responding in the C57 strain but not in DBA mice. An improvement in avoidance behaviour was observed following the administration of chlordiazepoxide in both strains of mice. Some favourable effects were obtained in DBA mice by combining morphine with chlordiazepoxide, whereas no interaction between these drugs was found in the C57 strain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
