We describe the application of fluorescence in situ hybridization (FISH) in a case of suspected chronic myelogenous leukemia (CML), cytogenetically characterized by a t(21;22) with no clear involvement of chromosome 9. The dual color FISH technique, performed using specific painting probes for chromosomes 9,21,22 and a BCR/ABL translocation probe, enabled us to confirm the diagnosis of CML by detecting the BCR/ABL rearrangement on chromosome 22q and the involvement of chromosome 9 in a variant translocation t(9;21;22).

Application of fluorescence in situ hybridization in defining a complex t(9;21;22)Ph formation / Mancini, M; Nanni, M; Cedrone, M; De Cuia, Mr; Rondinelli, Mb; Malagnino, F; Alimena, Giuliana. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 79:(1994), pp. 536-539.

Application of fluorescence in situ hybridization in defining a complex t(9;21;22)Ph formation.

ALIMENA, Giuliana
1994

Abstract

We describe the application of fluorescence in situ hybridization (FISH) in a case of suspected chronic myelogenous leukemia (CML), cytogenetically characterized by a t(21;22) with no clear involvement of chromosome 9. The dual color FISH technique, performed using specific painting probes for chromosomes 9,21,22 and a BCR/ABL translocation probe, enabled us to confirm the diagnosis of CML by detecting the BCR/ABL rearrangement on chromosome 22q and the involvement of chromosome 9 in a variant translocation t(9;21;22).
1994
CML; variant Ph translocation; FISH
01 Pubblicazione su rivista::01a Articolo in rivista
Application of fluorescence in situ hybridization in defining a complex t(9;21;22)Ph formation / Mancini, M; Nanni, M; Cedrone, M; De Cuia, Mr; Rondinelli, Mb; Malagnino, F; Alimena, Giuliana. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 79:(1994), pp. 536-539.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/406803
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 8
social impact