During treatment of chronic myeloid leukemia, imatinib plasma concentration can vary widely among patients. One of the possible reasons is the possible drug–drug interaction. Imatinib interacts with certain cytochrome P450 (CYP450) metabolizing enzymes and compete with several substances such as the less active isomer of warfarin [1]. For this reason, the concomitant use of imatinib and anticoagulant therapy is discouraged.

Concomitant use of imatinib and warfarin in chronic phase chronic myeloid leukemia patients does not interfere with drug efficacy / Breccia, M; Santopietro, M; Loglisci, G; Stagno, F; Cannella, L; Carmosino, I; Alimena, Giuliana. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 34:(2010), pp. 224-225. [10.1016/j.leukres.2010.03.015]

Concomitant use of imatinib and warfarin in chronic phase chronic myeloid leukemia patients does not interfere with drug efficacy.

Breccia M;ALIMENA, Giuliana
2010

Abstract

During treatment of chronic myeloid leukemia, imatinib plasma concentration can vary widely among patients. One of the possible reasons is the possible drug–drug interaction. Imatinib interacts with certain cytochrome P450 (CYP450) metabolizing enzymes and compete with several substances such as the less active isomer of warfarin [1]. For this reason, the concomitant use of imatinib and anticoagulant therapy is discouraged.
2010
Chronic myeloid leukemia; Imatinib; Warfarin
01 Pubblicazione su rivista::01a Articolo in rivista
Concomitant use of imatinib and warfarin in chronic phase chronic myeloid leukemia patients does not interfere with drug efficacy / Breccia, M; Santopietro, M; Loglisci, G; Stagno, F; Cannella, L; Carmosino, I; Alimena, Giuliana. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - STAMPA. - 34:(2010), pp. 224-225. [10.1016/j.leukres.2010.03.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/406127
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