Sensory neuropathy usually impairs tactile sensations related to large myelinated afferents (Abeta) as well as thermal-pain sense related to small myelinated (Adelta) and unmyelinated (C) afferents. By selectively affecting large or small fibres, some sensory neuropathies may also provoke a dissociated sensory loss. Standard nerve conduction studies and somatosensory evoked potentials assess Abeta-fibre function only. Laser pulses selectively excite free nerve endings in the superficial skin layers and evoke Adelta-related brain potentials (LEPs). From earlier studies and new cases we collected data on 270 patients with sensory neuropathy. LEPs often disclosed subclinical dysfunction of Adelta fibres and proved a sensitive and reliable diagnostic tool for assessing small-fibre function in sensory neuropathy.

Laser evoked potentials for assessing sensory neuropathy in human patients / Truini, Andrea; A., Romaniello; F., Galeotti; G. D., Iannetti; Cruccu, Giorgio. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 361:(2004), pp. 25-28. [10.1016/S0304-3940(03)01388-0]

Laser evoked potentials for assessing sensory neuropathy in human patients.

TRUINI, ANDREA;CRUCCU, Giorgio
2004

Abstract

Sensory neuropathy usually impairs tactile sensations related to large myelinated afferents (Abeta) as well as thermal-pain sense related to small myelinated (Adelta) and unmyelinated (C) afferents. By selectively affecting large or small fibres, some sensory neuropathies may also provoke a dissociated sensory loss. Standard nerve conduction studies and somatosensory evoked potentials assess Abeta-fibre function only. Laser pulses selectively excite free nerve endings in the superficial skin layers and evoke Adelta-related brain potentials (LEPs). From earlier studies and new cases we collected data on 270 patients with sensory neuropathy. LEPs often disclosed subclinical dysfunction of Adelta fibres and proved a sensitive and reliable diagnostic tool for assessing small-fibre function in sensory neuropathy.
2004
Evoked Potentials; Somatosensory; physiology/radiation effects; Humans; Lasers; diagnostic use; Nerve Fibers; Myelinated; Unmyelinated; Peripheral Nervous System Diseases; diagnosis/physiopathology; Physical Stimulation; instrumentation/methods; Predictive Value of Tests; Reproducibility of Results; Sensitivity and Specificity; Sensory Receptor Cells; Somatosensory Disorders
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Laser evoked potentials for assessing sensory neuropathy in human patients / Truini, Andrea; A., Romaniello; F., Galeotti; G. D., Iannetti; Cruccu, Giorgio. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 361:(2004), pp. 25-28. [10.1016/S0304-3940(03)01388-0]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/405558
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