The median age of chronic myeloid leukemia (CML) patients is similar to 60 years, and age is still considered an important prognostic factor, included in Sokal and EURO risk scores. However, few data are available about the long-term outcome of older patients treated with imatinib (IM) frontline. We analyzed the relationship between age and outcome in 559 early chronic-phase CML patients enrolled in 3 prospective clinical trials of Gruppo Italiano Malattie Ematologiche dell'Adulto CML Working Party, treated frontline with IM, with a median follow-up of 60 months. There were 115 older patients (>= 65 years; 21%). The complete cytogenetic and major molecular response rates were similar in the 2 age groups. In older patients, event-free survival (55% vs 67%), failure-free survival (78% vs 92%), progression-free survival (62% vs 78%), and overall survival (75% vs 89%) were significantly inferior (all P<.01) because of a higher proportion of deaths that occurred in complete hematologic response, therefore unrelated to CML progression (15% vs 3%, P<.0001). The outcome was similar once those deaths were censored. These data show that response to IM was not affected by age and that the mortality rate linked to CML is similar in both age groups. This trial was registered at www.clinicaltrials.gov as #NCT00514488 and # NCT00510926. (Blood. 2011; 117(21): 5591-5599)

Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML Working Party / G., Gugliotta; F., Castagnetti; F., Palandri; M., Breccia; T., Intermesoli; A., Capucci; B., Martino; P., Pregno; S., Rupoli; D., Ferrero; F., Gherlinzoni; E., Montefusco; M., Bocchia; M., Tiribelli; I., Pierri; F., Grifoni; G., Marzocchi; M., Amabile; N., Testoni; Martinelli, Giovanni; Alimena, Giuliana; F., Pane; G., Saglio; M., Baccarani; Rosti G., Gruppo Italiano Malattie Ematologiche Dell'Adulto Cml Working Party. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 117:21(2011), pp. 5591-5599. [10.1182/blood-2010-12-324228]

Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML Working Party

M. Breccia;MARTINELLI, GIOVANNI;ALIMENA, Giuliana;
2011

Abstract

The median age of chronic myeloid leukemia (CML) patients is similar to 60 years, and age is still considered an important prognostic factor, included in Sokal and EURO risk scores. However, few data are available about the long-term outcome of older patients treated with imatinib (IM) frontline. We analyzed the relationship between age and outcome in 559 early chronic-phase CML patients enrolled in 3 prospective clinical trials of Gruppo Italiano Malattie Ematologiche dell'Adulto CML Working Party, treated frontline with IM, with a median follow-up of 60 months. There were 115 older patients (>= 65 years; 21%). The complete cytogenetic and major molecular response rates were similar in the 2 age groups. In older patients, event-free survival (55% vs 67%), failure-free survival (78% vs 92%), progression-free survival (62% vs 78%), and overall survival (75% vs 89%) were significantly inferior (all P<.01) because of a higher proportion of deaths that occurred in complete hematologic response, therefore unrelated to CML progression (15% vs 3%, P<.0001). The outcome was similar once those deaths were censored. These data show that response to IM was not affected by age and that the mortality rate linked to CML is similar in both age groups. This trial was registered at www.clinicaltrials.gov as #NCT00514488 and # NCT00510926. (Blood. 2011; 117(21): 5591-5599)
2011
bone-marrow-transplantation; chronic myelogenous leukemia; complete cytogenetic response; early chronic phase; elderly-patients; european-leukemianet; interferon-alpha; line treatment; mesylate therapy; patients receiving imatinib
01 Pubblicazione su rivista::01a Articolo in rivista
Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML Working Party / G., Gugliotta; F., Castagnetti; F., Palandri; M., Breccia; T., Intermesoli; A., Capucci; B., Martino; P., Pregno; S., Rupoli; D., Ferrero; F., Gherlinzoni; E., Montefusco; M., Bocchia; M., Tiribelli; I., Pierri; F., Grifoni; G., Marzocchi; M., Amabile; N., Testoni; Martinelli, Giovanni; Alimena, Giuliana; F., Pane; G., Saglio; M., Baccarani; Rosti G., Gruppo Italiano Malattie Ematologiche Dell'Adulto Cml Working Party. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 117:21(2011), pp. 5591-5599. [10.1182/blood-2010-12-324228]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/405409
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 91
  • ???jsp.display-item.citation.isi??? 82
social impact