The subcortical integrative effects of laser-induced activation of pain ascending tracts were examined in 11 healthy volunteers, aged 22-52 years. Subjects underwent either CO2 laser stimulation at the dorsum of the hand, electrical stimulation of digital nerves at the 3rd finger, or mechanical taps to the first dorsal interosseous space, preceding a blink reflex elicited by a supraorbital nerve electrical stimulus. The percentage inhibition induced in the R2 response of the blink reflex was similar for the three different stimulus modalities, but occurred at a different time interval. Compared to control trials, the R2 response of the test trials was a mean of 23.1% at the interval of 250 ms with laser stimuli, 17.4% at the interval of 100 ms with electrical stimuli to the 3rd finger, and 20.6% at the interval of 90 ms with a mechanical tap to the Ist interosseous space. Activation of pain receptors induce prepulse inhibition of the blink reflex at a delay corresponding to a slowly conducting pathway. The percentage inhibition is similar to that observed with other somatosensory inputs. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

Prepulse inhibition of the blink reflex by laser stimuli in normal humans / Josep Valls, Sole; Misericordia, Veciana; Jordi, Serra; Cruccu, Giorgio; Antonella, Romaniello. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 286:2(2000), pp. 79-82. [10.1016/s0304-3940(00)01085-5]

Prepulse inhibition of the blink reflex by laser stimuli in normal humans

CRUCCU, Giorgio;
2000

Abstract

The subcortical integrative effects of laser-induced activation of pain ascending tracts were examined in 11 healthy volunteers, aged 22-52 years. Subjects underwent either CO2 laser stimulation at the dorsum of the hand, electrical stimulation of digital nerves at the 3rd finger, or mechanical taps to the first dorsal interosseous space, preceding a blink reflex elicited by a supraorbital nerve electrical stimulus. The percentage inhibition induced in the R2 response of the blink reflex was similar for the three different stimulus modalities, but occurred at a different time interval. Compared to control trials, the R2 response of the test trials was a mean of 23.1% at the interval of 250 ms with laser stimuli, 17.4% at the interval of 100 ms with electrical stimuli to the 3rd finger, and 20.6% at the interval of 90 ms with a mechanical tap to the Ist interosseous space. Activation of pain receptors induce prepulse inhibition of the blink reflex at a delay corresponding to a slowly conducting pathway. The percentage inhibition is similar to that observed with other somatosensory inputs. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
2000
adult; blink reflex; blinking; brainstem; cytology/physiology; electric stimulation; female; humans; laser; lasers; male; middle aged; neural inhibition; nociceptors; pain; pain threshold; physical stimulation; physiology; physiopathology; prepulse inhibition; reaction time; reticular formation; spinothalamic tracts; time factors
01 Pubblicazione su rivista::01a Articolo in rivista
Prepulse inhibition of the blink reflex by laser stimuli in normal humans / Josep Valls, Sole; Misericordia, Veciana; Jordi, Serra; Cruccu, Giorgio; Antonella, Romaniello. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 286:2(2000), pp. 79-82. [10.1016/s0304-3940(00)01085-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/405291
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