Purpose of review We reviewed recent clinical studies performed in adults, children, and neonates exploring the possible association of gastric acidity inhibitors use with intestinal infections. Possible mechanisms have also been reported. Recent findings Many studies and systematic reviews demonstrate an increased risk of bacterial infection in adults taking acid suppressors. Little evidence is derived from the pediatric population. The use of gastric acidity inhibitors has been associated with systemic infections and necrotizing enterocolitis in preterm infants. Reduced gastric acidity, delayed gastric emptying, increased gastric mucus viscosity, modification in microbiota, and impairment of neutrophils functions, are all conditions determined by gastric acidity blockers that potentially lead to an increased risk of gastrointestinal infections. Summary A proper utilization of these drugs, particularly for patients at high risk, is imperative in order to reduce deleterious effects on infection risk and to optimize cost-effectiveness ratio.

Gastric acidity inhibitors and the risk of intestinal infections / Roberto Berni, Canani; Terrin, Gianluca. - In: CURRENT OPINION IN GASTROENTEROLOGY. - ISSN 0267-1379. - 26:1(2010), pp. 31-35. [10.1097/mog.0b013e328333d781]

Gastric acidity inhibitors and the risk of intestinal infections

TERRIN, GIANLUCA
2010

Abstract

Purpose of review We reviewed recent clinical studies performed in adults, children, and neonates exploring the possible association of gastric acidity inhibitors use with intestinal infections. Possible mechanisms have also been reported. Recent findings Many studies and systematic reviews demonstrate an increased risk of bacterial infection in adults taking acid suppressors. Little evidence is derived from the pediatric population. The use of gastric acidity inhibitors has been associated with systemic infections and necrotizing enterocolitis in preterm infants. Reduced gastric acidity, delayed gastric emptying, increased gastric mucus viscosity, modification in microbiota, and impairment of neutrophils functions, are all conditions determined by gastric acidity blockers that potentially lead to an increased risk of gastrointestinal infections. Summary A proper utilization of these drugs, particularly for patients at high risk, is imperative in order to reduce deleterious effects on infection risk and to optimize cost-effectiveness ratio.
2010
clostridium difficile; diarrhea; histamine 2 receptor antagonists; neonates; proton pump inhibitors
01 Pubblicazione su rivista::01a Articolo in rivista
Gastric acidity inhibitors and the risk of intestinal infections / Roberto Berni, Canani; Terrin, Gianluca. - In: CURRENT OPINION IN GASTROENTEROLOGY. - ISSN 0267-1379. - 26:1(2010), pp. 31-35. [10.1097/mog.0b013e328333d781]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/402554
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