To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight < 1500 g and a postnatal age > 72 hours of life. The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-total-neutrophil ratio, platelet count, and C-reactive protein). We found that the serum calprotectin concentration was significantly higher (P < .001) in 62 newborns with confirmed sepsis (3.1 +/- 1.0 mu g/mL) than in either 29 noninfected subjects (1.1 +/- 0.3 mu g/ml) or 110 healthy controls (0.91 +/- 0.58 mu g/ml). The diagnostic accuracy of serum calprotectin was greater (sensitivity 89%, specificity 96%) than that of the traditional markers of sepsis. In conclusion, serum calprotectin is an accurate marker of sepsis in very low birth weight newborns.

Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns / Terrin, Gianluca; Annalisa, Passariello; Francesco, Manguso; Gennaro, Salvia; Luciano, Rapacciuolo; Francesco, Messina; Francesco, Raimondi; Roberto Berni, Canani. - In: CLINICAL & DEVELOPMENTAL IMMUNOLOGY. - ISSN 1740-2522. - 2011:(2011), pp. 1-6. [10.1155/2011/291085]

Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns

TERRIN, GIANLUCA;
2011

Abstract

To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight < 1500 g and a postnatal age > 72 hours of life. The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-total-neutrophil ratio, platelet count, and C-reactive protein). We found that the serum calprotectin concentration was significantly higher (P < .001) in 62 newborns with confirmed sepsis (3.1 +/- 1.0 mu g/mL) than in either 29 noninfected subjects (1.1 +/- 0.3 mu g/ml) or 110 healthy controls (0.91 +/- 0.58 mu g/ml). The diagnostic accuracy of serum calprotectin was greater (sensitivity 89%, specificity 96%) than that of the traditional markers of sepsis. In conclusion, serum calprotectin is an accurate marker of sepsis in very low birth weight newborns.
2011
01 Pubblicazione su rivista::01a Articolo in rivista
Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns / Terrin, Gianluca; Annalisa, Passariello; Francesco, Manguso; Gennaro, Salvia; Luciano, Rapacciuolo; Francesco, Messina; Francesco, Raimondi; Roberto Berni, Canani. - In: CLINICAL & DEVELOPMENTAL IMMUNOLOGY. - ISSN 1740-2522. - 2011:(2011), pp. 1-6. [10.1155/2011/291085]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/402428
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