McCune- Albright syndrome: evidence for autonomous multiendocrine hyperfunction

The triad of sexual precocity, polyostotic fibrous dysplasia, and cutaneous pigmentation is known as McCune-Albright syndrome. Recently, additional endocrinologic disorders have been described as part of this syndrome, including hyperthyroidism, acromegalt, hyperparathyroidism, and Cushing syndrome. The cause of the syndrome is still unknown; central or peripheral origin of the sexual precocity and of the endocrinologic abnormalities has been postulated. We report a girl with Mc-Cune-Albright syndrome in whom there is evidence that sexual precocity and hyperthyroidism result from the autonomous acitvity of ovaries and thyroid gland.