Objective - The aim of the study was to evaluate the impact of irregular cycles on bone mass in perimenopausal women. Setting - University clinic. Patients and Methods - 118 healthy women aged between 45 and 55 years were divided into three groups according to the previous year's menstrual history (premenopause: regular cycles; perimenopause: irregular cycles; early postmenopause: 1-3 years since the last menstrual cycle. Among the perimenopausal group, only women presenting intervals without menstruation longer than 3 months during the year of the study were selected. Bone mineral density of the lumbar spine and of the proximal femur was measured by dual energy X-ray absorptiometry (DEXA) at the start of the study and after 12 months. Results - The serum estradiol level was significantly lower in postmenopausal women and the FSH serum level showed a significant increase in perimenopausal and postmenopausal women in comparison with premenopausal controls. Bone density at L2-L4, femoral neck, greater trochanter, and total femur did not show significant differences at the beginning of the between-group study. Only the density in Ward's triangle was significantly lower in perimenopausal and postmenopausal women. After twelve months the densities of L2-L4, greater trochanter, Ward's triangle, and total femur showed a significant decrease in postmenopausal women in comparison. The perimenopausal group showed a significant decrease in total femur and Ward's triangle density in comparison with premenopausal. Conclusion - The occurrence of marked irregularity of menstrual cycles preceding menopause can influence bone mass, in particular at the femoral site.
LUMBAR AND FEMORAL BONE-DENSITY IN PERIMENOPAUSAL WOMEN WITH IRREGULAR CYCLES / Perrone, Giuseppina; Galoppi, Paola; Capri, Oriana; G., Anelli; M., Borrello; L., Zichella. - In: INTERNATIONAL JOURNAL OF FERTILITY AND MENOPAUSAL STUDIES. - ISSN 1069-3130. - 40:3(1995), pp. 120-125.
LUMBAR AND FEMORAL BONE-DENSITY IN PERIMENOPAUSAL WOMEN WITH IRREGULAR CYCLES
PERRONE, Giuseppina;GALOPPI, Paola;CAPRI, Oriana;
1995
Abstract
Objective - The aim of the study was to evaluate the impact of irregular cycles on bone mass in perimenopausal women. Setting - University clinic. Patients and Methods - 118 healthy women aged between 45 and 55 years were divided into three groups according to the previous year's menstrual history (premenopause: regular cycles; perimenopause: irregular cycles; early postmenopause: 1-3 years since the last menstrual cycle. Among the perimenopausal group, only women presenting intervals without menstruation longer than 3 months during the year of the study were selected. Bone mineral density of the lumbar spine and of the proximal femur was measured by dual energy X-ray absorptiometry (DEXA) at the start of the study and after 12 months. Results - The serum estradiol level was significantly lower in postmenopausal women and the FSH serum level showed a significant increase in perimenopausal and postmenopausal women in comparison with premenopausal controls. Bone density at L2-L4, femoral neck, greater trochanter, and total femur did not show significant differences at the beginning of the between-group study. Only the density in Ward's triangle was significantly lower in perimenopausal and postmenopausal women. After twelve months the densities of L2-L4, greater trochanter, Ward's triangle, and total femur showed a significant decrease in postmenopausal women in comparison. The perimenopausal group showed a significant decrease in total femur and Ward's triangle density in comparison with premenopausal. Conclusion - The occurrence of marked irregularity of menstrual cycles preceding menopause can influence bone mass, in particular at the femoral site.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.