Liver biopsy is the gold standard in the evaluation of liver disease and remains the most direct way of visualizing hepatic necro-inflammation and fibrosis. A given liver biopsy sample in chronic hepatitis is a ‘‘snapshot’’ of the current necro-inflammatory activity at the time the sample is obtained. However, necro-inflammation is a dynamic process that may change over time, so that paired or multiple biopsies may show significant differences in each of the essential components outlined earlier. For this study were randomly enrolled 100 patients, including: 30 patients with normal histological examination performed for suspected disease, 70 patients with positive histology for steatosis. One hundred images were analyzed for a total of 1120 sinusoids. We found that in some specimens with 30% steatosis, the sinusoids showed the shape and hydraulic resistance are comparable to specimens with 70-75% steatosis. These findings, that will be tested in follow-up, could be steatosis with a rapid progression of the disease.
Preliminary Study of Sinusoids Area in the Progression of Liver Disease / Marinozzi, Franco; Novelli, S.; Morabito, VINCENZO EMILIANO; Rossi, Massimo; Bini, Fabiano. - ELETTRONICO. - (2011). (Intervento presentato al convegno EASL Monothematic Conference, Evaluation of Disease Severity and Prognosis in Chronic Liver Disease tenutosi a Nice, France nel 28-29 january 2011).