3',5'-adenosine monophosphate (cAMP), adenylate cyclase and cAMP-phosphodiesterase (PDE) activity were measured in aorta homogenates from normal and spontaneously hypertensive rats (SHR) during treatment with prazosin, an antihypertensive drug. cAMP levels were lower in SHR than in normal rats. In SHR prazosin treatment induced marked inhibition of PDE activity thus causing an increase in cAMP levels; adenylate cyclase activity remained unaffected. This effect was only present for the first 32 days of drug administration.
Effects of prazosin on the cAMP system in the sphontaneously hypertensive rat aorta / D'Armiento, Massimino; F., Lacerna; R., Lauro; Modesti, Mauro; Verna, Roberto; G., Ceccarelli. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 65:(1980), pp. 243-247.
Effects of prazosin on the cAMP system in the sphontaneously hypertensive rat aorta
D'ARMIENTO, Massimino;MODESTI, Mauro;VERNA, Roberto;
1980
Abstract
3',5'-adenosine monophosphate (cAMP), adenylate cyclase and cAMP-phosphodiesterase (PDE) activity were measured in aorta homogenates from normal and spontaneously hypertensive rats (SHR) during treatment with prazosin, an antihypertensive drug. cAMP levels were lower in SHR than in normal rats. In SHR prazosin treatment induced marked inhibition of PDE activity thus causing an increase in cAMP levels; adenylate cyclase activity remained unaffected. This effect was only present for the first 32 days of drug administration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
