The cyclic AMP content and its relationship with thyroglobulin biosynthesis is determined in the experimental transplantable tumor (Wollman Line 1-1C2) in which it was previously shown a lack of sialic acid incorporation into thyroglobulin. The tumor has lower cyclic AMP content than the thyroid. The impaired thyroglobulin biosynthesis and the defective incorporation of N-acetylmannosamine into thyroglobulin is restored towards normal by the cyclic AMP analogous dibutyryl cyclic AMP. The in vitro addition to tumor slices of dibutryl cyclic AMP enhances leucine and restores to normal level sialic acid incorporation into thyroglobulin. These results indicate that the defective thyroglobulin biosynthesis is related to the low cyclic AMP content of the thyroid tumor tissue.
Cyclic AMP and thyroglobulin biosynthesis in the experimental rat thyroid tumor / D'Armiento, Massimino; F., Monaco. - In: BIOCHIMICA ET BIOPHYSICA ACTA. - ISSN 0006-3002. - STAMPA. - 372:1(1974), pp. 176-182. [10.1016/0304-4165(74)90085-3]
Cyclic AMP and thyroglobulin biosynthesis in the experimental rat thyroid tumor.
D'ARMIENTO, Massimino;
1974
Abstract
The cyclic AMP content and its relationship with thyroglobulin biosynthesis is determined in the experimental transplantable tumor (Wollman Line 1-1C2) in which it was previously shown a lack of sialic acid incorporation into thyroglobulin. The tumor has lower cyclic AMP content than the thyroid. The impaired thyroglobulin biosynthesis and the defective incorporation of N-acetylmannosamine into thyroglobulin is restored towards normal by the cyclic AMP analogous dibutyryl cyclic AMP. The in vitro addition to tumor slices of dibutryl cyclic AMP enhances leucine and restores to normal level sialic acid incorporation into thyroglobulin. These results indicate that the defective thyroglobulin biosynthesis is related to the low cyclic AMP content of the thyroid tumor tissue.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
