Novel star-branched polymers were synthesized by ring-opening polymerization of e-caprolactone (CL) with tetraethylenepentamine (TEPA) as polyfunctional initiator. Different [CL]/[TEPA] molar ratios were used. A branched polymer having five arms and a DPn,exp@DPn,teor was obtained only for [CL]/[TEPA]=50 ratio. The TPCLs were employed to prepare nanoparticles on which a model antibiotic was adsorbed. The significant amount of drug adsorbed onto TPCL50 opens interesting perspectives for the use of this system in the drug delivery field.
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|Titolo:||Synthesis and properties of star-branched polymers for pharmaceutical applications|
|Data di pubblicazione:||2011|
|Appartiene alla tipologia:||04a Atto di comunicazione a congresso|