Vascular profile, delayed recovery, inflammatory process, and ambulatory blood pressure: laboratory-to-life generalizability

Impaired recovery and plasma concentration of intercellular adhesion molecule-1 (sICAM-1) were both highlighted as plausible and more established markers of cardiovascular disease, respectively. Hemodynamic patterns during recovery and their link with circulating levels of sICAM-1 were examined as predictors of 24-h blood pressure (ABP). Impedance cardiography measures and beat-to-beat BP were recorded in 45 healthy subjects during a 10-min baseline, four tasks, and four 10-min recovery periods. sICAM-1 levels at rest were determined by ELISA. ABP measures were obtained combining data from a work and an off day. Hierarchical regressions showed that patterns of compensatory changes in cardiac output and total peripheral resistance during recovery improved the prediction of ABP above and beyond resting and recovery BP, or reactivity hemodynamic patterns. Stress-induced recovery was essentially vascular in nature and a more vascular profile was associated with higher ABP and higher circulating levels of sICAM-1. The results suggest a link between recovery hemodynamics and cardiovascular risk. (C) 2007 Elsevier B.V. All rights reserved.