Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.

[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast] / A., Modesti; G., D'Orazi; Scarpa, Susanna; Mezi, Silvia; F., Gatti; G., Aloise; D., Gerace; P., Guglielmi; L., Simonelli; Modesti, Mauro. - In: IL GIORNALE DI CHIRURGIA. - ISSN 0391-9005. - 10:5(1989), pp. 245-249.

[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast].

SCARPA, Susanna;MEZI, Silvia;MODESTI, Mauro
1989

Abstract

Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.
1989
01 Pubblicazione su rivista::01a Articolo in rivista
[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast] / A., Modesti; G., D'Orazi; Scarpa, Susanna; Mezi, Silvia; F., Gatti; G., Aloise; D., Gerace; P., Guglielmi; L., Simonelli; Modesti, Mauro. - In: IL GIORNALE DI CHIRURGIA. - ISSN 0391-9005. - 10:5(1989), pp. 245-249.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/399890
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