Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.

[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast] / A., Modesti; G., D'Orazi; Scarpa, Susanna; Mezi, Silvia; F., Gatti; G., Aloise; D., Gerace; P., Guglielmi; L., Simonelli; Modesti, Mauro. - In: IL GIORNALE DI CHIRURGIA. - ISSN 0391-9005. - 10:5(1989), pp. 245-249.

[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast].

SCARPA, Susanna;MEZI, Silvia;MODESTI, Mauro
1989

Abstract

Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/399890
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