Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.
[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast] / A., Modesti; G., D'Orazi; Scarpa, Susanna; Mezi, Silvia; F., Gatti; G., Aloise; D., Gerace; P., Guglielmi; L., Simonelli; Modesti, Mauro. - In: IL GIORNALE DI CHIRURGIA. - ISSN 0391-9005. - 10:5(1989), pp. 245-249.
[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast].
SCARPA, Susanna;MEZI, Silvia;MODESTI, Mauro
1989
Abstract
Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.