{This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.}
Reconstitution of aluminium and iron core in horse spleen apoferritin / Ciasca, Gabriele; M., Chiarpotto; G., Campi; B., Bocca; M., Rodio; A., Pino; Ricci, Alessandro; Poccia, Nicola; C., Rossi; A., Alimonti; H., Amenitsch; P. D., Sole; Bianconi, Antonio. - In: JOURNAL OF NANOPARTICLE RESEARCH. - ISSN 1388-0764. - STAMPA. - (2011), pp. 1-7. [10.1007/s11051-011-0294-2]
Reconstitution of aluminium and iron core in horse spleen apoferritin
CIASCA, Gabriele;RICCI, ALESSANDRO;POCCIA, NICOLA;BIANCONI, Antonio
2011
Abstract
{This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4 −, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.}I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
