Authors treated 4 patients suffering from advanced ovarian cancer with high-dose chemotherapy and autologous peripheral blood stem cell (APBSC) or autologous bone marrow stem cell (ABM) as hematopoietic support. In three patients were collected peripheral blood stem cells using a fully automated blood cell separator during hematopoietic recovery following aplasia induced by non-intensive chemotherapy (cisplatin 200 mg/m2 and cyclophosphamide 1,500 mg/m2). Hemopoietic reconstitution of the four patients submitted to APBSC or ABM support after high-dose chemotherapy (cisplatin 100 mg/m2, VP16 650 mg/m2 and carboplatin 1,800 mg/m2) showed the low hematological toxicity of our treatment with APBSC support. Moreover, the drug combination of cisplatin and cyclophosphamide has clinical activity in ovarian cancer and it is an optimal association to mobilize and harvest large number of PBSC.

High dose chemotherapy with cisplatin, VP16 and carboplatin with stem cell support in patients with advanced ovarian cancer / Pierelli, Luca; G., Menichella; M. L., Foddai; R., Serafini; M., Vittori; A., Paoloni; Panici, P. B.; G., Scambia; G., Baiocchi; S., Greggi. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 76 Suppl 1:(1991), pp. 63-65.

High dose chemotherapy with cisplatin, VP16 and carboplatin with stem cell support in patients with advanced ovarian cancer.

PIERELLI, LUCA;P. B. Panici;
1991

Abstract

Authors treated 4 patients suffering from advanced ovarian cancer with high-dose chemotherapy and autologous peripheral blood stem cell (APBSC) or autologous bone marrow stem cell (ABM) as hematopoietic support. In three patients were collected peripheral blood stem cells using a fully automated blood cell separator during hematopoietic recovery following aplasia induced by non-intensive chemotherapy (cisplatin 200 mg/m2 and cyclophosphamide 1,500 mg/m2). Hemopoietic reconstitution of the four patients submitted to APBSC or ABM support after high-dose chemotherapy (cisplatin 100 mg/m2, VP16 650 mg/m2 and carboplatin 1,800 mg/m2) showed the low hematological toxicity of our treatment with APBSC support. Moreover, the drug combination of cisplatin and cyclophosphamide has clinical activity in ovarian cancer and it is an optimal association to mobilize and harvest large number of PBSC.
1991
Adult; Antineoplastic Combined Chemotherapy Protocols; adverse effects/therapeutic use; Bone Marrow Transplantation; Bone Marrow; drug effects/pathology; Carboplatin; administration /&/ dosage/adverse effects; Cisplatin; administration /&/ dosage/adverse effects/pharmacology; Combined Modality Therapy; Cyclophosphamide; administration /&/ dosage/pharmacology; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Middle Aged; Ovarian Neoplasms; drug therapy/surgery/therapy; Pancytopenia; chemically induced/surgery/therapy; Transplantation; Autologous
01 Pubblicazione su rivista::01a Articolo in rivista
High dose chemotherapy with cisplatin, VP16 and carboplatin with stem cell support in patients with advanced ovarian cancer / Pierelli, Luca; G., Menichella; M. L., Foddai; R., Serafini; M., Vittori; A., Paoloni; Panici, P. B.; G., Scambia; G., Baiocchi; S., Greggi. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 76 Suppl 1:(1991), pp. 63-65.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/399334
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 3
  • ???jsp.display-item.citation.isi??? ND
social impact