Six patients with advanced ovarian carcinoma (OvCa), and six patients with stage II or III resectable breast cancer (BrCa) were treated with low-dose CY (LD-CY, 1500 mg/m(2)) and cisplatin (CDDP) 100 mg/m(2) (OvCa) or epirubicin (EPR) 120 mg/m(2) (BrCa) plus recombinant human G-CSF (rhG-CSF). Twelve days after chemotherapy, all patients underwent PBSC collection on an outpatient basis, Following the completion of the induction programme, all patients underwent high-dose chemotherapy (HDC) with carboplatin 1200 mg/m(2), etoposide 900 mg/m(2) and melphalan 100 mg/m(2) with the reinfusion of PBSC. LD-CY plus rhG-CSF in combination with CDDP or EPR mobilised a very large number of PBSC. After a median of 13 days from chemotherapy, the concentration of PBSC in the peripheral blood was 40-fold higher than the same patient's baseline value. Each collection yielded a median of 10.8 x 10(4)/kg colony-forming unit granulocyte-macrophage. Severe myelosuppression occurred in all patients following HDC, but the infusion of PBSC produced a rapid and sustained haemopoietic recovery. After a median of 11 days from reinfusion, haemopoietic engraftment was complete and 80% of the patients had platelets > 100 x 10(9)/l and PMN > 1 X 10(9)/l within 14 days after reinfusion. We can conclude that the present therapeutic approach is an excellent option for mobilisation, collection and transplantation of PBSC during intensive dose adjuvant polychemotherapy of high-risk cancer.

LOW-DOSE CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN OR EPIRUBICIN PLUS RHG-CSF ALLOWS ADEQUATE COLLECTION OF PBSC FOR AUTOTRANSPLANTATION DURING ADJUVANT THERAPY FOR HIGH-RISK CANCER / G., Menichella; Pierelli, Luca; G., Scambia; G., Salerno; Panici, P. B.; M. L., Foddai; R., Serafini; G., Puglia; M., Lai; M., Ciarli. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - 14:6(1994), pp. 907-912.

LOW-DOSE CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN OR EPIRUBICIN PLUS RHG-CSF ALLOWS ADEQUATE COLLECTION OF PBSC FOR AUTOTRANSPLANTATION DURING ADJUVANT THERAPY FOR HIGH-RISK CANCER

PIERELLI, LUCA;P. B. Panici;
1994

Abstract

Six patients with advanced ovarian carcinoma (OvCa), and six patients with stage II or III resectable breast cancer (BrCa) were treated with low-dose CY (LD-CY, 1500 mg/m(2)) and cisplatin (CDDP) 100 mg/m(2) (OvCa) or epirubicin (EPR) 120 mg/m(2) (BrCa) plus recombinant human G-CSF (rhG-CSF). Twelve days after chemotherapy, all patients underwent PBSC collection on an outpatient basis, Following the completion of the induction programme, all patients underwent high-dose chemotherapy (HDC) with carboplatin 1200 mg/m(2), etoposide 900 mg/m(2) and melphalan 100 mg/m(2) with the reinfusion of PBSC. LD-CY plus rhG-CSF in combination with CDDP or EPR mobilised a very large number of PBSC. After a median of 13 days from chemotherapy, the concentration of PBSC in the peripheral blood was 40-fold higher than the same patient's baseline value. Each collection yielded a median of 10.8 x 10(4)/kg colony-forming unit granulocyte-macrophage. Severe myelosuppression occurred in all patients following HDC, but the infusion of PBSC produced a rapid and sustained haemopoietic recovery. After a median of 11 days from reinfusion, haemopoietic engraftment was complete and 80% of the patients had platelets > 100 x 10(9)/l and PMN > 1 X 10(9)/l within 14 days after reinfusion. We can conclude that the present therapeutic approach is an excellent option for mobilisation, collection and transplantation of PBSC during intensive dose adjuvant polychemotherapy of high-risk cancer.
1994
administration /&/ dosage; adult; autologous; breast neoplasms; cisplatin; combined modality therapy; cyclophosphamide; epirubicin; female; granulocyte colony-stimulating factor; hematopoiesis; hematopoietic stem cell transplantation; humans; methods; middle aged; ovarian neoplasms; therapy; transplantation
01 Pubblicazione su rivista::01a Articolo in rivista
LOW-DOSE CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN OR EPIRUBICIN PLUS RHG-CSF ALLOWS ADEQUATE COLLECTION OF PBSC FOR AUTOTRANSPLANTATION DURING ADJUVANT THERAPY FOR HIGH-RISK CANCER / G., Menichella; Pierelli, Luca; G., Scambia; G., Salerno; Panici, P. B.; M. L., Foddai; R., Serafini; G., Puglia; M., Lai; M., Ciarli. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - 14:6(1994), pp. 907-912.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/399312
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 21
social impact